摘要
目的观察荆蝉止嗽颗粒治疗咳嗽变异性哮喘的临床疗效及对气道炎症的影响。方法将符合纳入标准的100例咳嗽变异性哮喘患者随机分为2组,对照组50例给予布地奈德福莫特罗粉吸入剂(160μg/4.5μg)早晚各2吸,治疗组在对照组治疗基础上加服荆蝉止嗽颗粒,1剂/d。2组疗程均为8周。统计2组治疗效果,观察2组治疗前后呼出气一氧化氮(FeNO)水平及外周血嗜酸性粒细胞(EOS)计数、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-10水平变化情况,并记录治疗期间2组不良反应发生情况。结果治疗组总有效率显著高于对照组(P<0.05)。2组治疗后FeNO、外周血EOS计数及血清TNF-α、IL-6水平均显著降低(P均<0.05),且治疗组显著低于对照组(P均<0.05);2组治疗后血清IL-10水平均显著升高(P均<0.05),且治疗组显著高于对照组(P<0.05)。治疗期间治疗组不良反应发生率显著低于对照组(P<0.05)。结论荆蝉止嗽颗粒联合布地奈德福莫特罗粉吸入剂治疗咳嗽变异性哮喘效果显著优于单用布地奈德福莫特罗粉吸入剂治疗,可显著减轻患者气道炎症,且不良反应少。
Objective It is to observe the clinical efficacy of Jingchan-Zhisou Granule in the treatment of cough variant asthma and its effect on airway inflammation. Methods One hundred patients with cough variant asthma who met the inclusion criteria were randomly divided into 2 groups. 50 patients in the control group were given budesonide fumotrol powder inhalation(160 μg/4.5 μg) in the morning and evening, respectively. 50 patients in the treatment group were treated with Jingchan-Zhisou Granule on the basis of treatment in the control group, 1 dose/d. Both courses of treatments were 8 weeks. The therapeutic effects of the two groups were statistically analyzed. The changes of the levels of exhaled nitric oxide(FeNO) and peripheral blood eosinophils(EOS), tumor necrosis factor-α(TNF-α), and interleukin-6(IL-6), IL-10 were observed before and after treatment, and the incidence of adverse reactions in the two groups during treatment was recorded. Results The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05). The levels of FeNO, peripheral blood EOS and serum TNF-α and IL-6 in the two groups were significantly decreased after treatment(P<0.05), and the decrease in the treatment group was more significant than that in the control group(P<0.05). The level of IL-10 level was significantly increased after treatment in the two groups(P<0.05), and the increase in the treatment group was more significant than that in the control group(P<0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group(P<0.05). Conclusion Jingchan-Zhisou Granule combined with budesonide momotrol powder inhalation which can significantly reduce airway inflammation in patients with less reaction has better curative effect on cough variant asthma than budesonide momotrol powder inhalation alone.
作者
贾琳
李博林
刘海叶
观云
JIA Lin;LI Bolin;LIU Haiye;GUAN Yun(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050031,Hebei,China;Hebei College of Traditional Chinese Medicine,Shijiazhuang 050200,Hebei,China)
出处
《现代中西医结合杂志》
CAS
2019年第10期1027-1031,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河北省科技计划项目(16277726D)
河北省中医药管理局课题(2016032)
政府资助临床医学优秀人才培养项目(2015054965)
