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手足口病患儿241例外周血T细胞亚群临床分析 被引量:2

Clinical analysis of 241 cases of hand foot and mouth disease in peripheral blood T cell subsets in children
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摘要 目的:探讨手足口病患儿T细胞亚群变化与病情严重程度的关系。方法:2011年6月-2013年7月收治手足口病患儿241例,分为重症组74例和轻症组167例;重症患儿中分为EV71阳性组(47例)与EB71阴性组(27例)。以流式细胞仪检测T细胞亚群(CD3+、CD4+、CD8+)百分率,并计算CD4+/CD8+比值,与同龄儿正常值进行对比。结果:轻症组167例患儿急性期T细胞亚群百分率与同龄儿正常参考水平一致。轻症组与重症组在CD3+、CD4+、CD8+及CD4+/CD8+比较,差异有统计学意义(P<0.05);重症患儿中EV71阳性组与EV71阴性组在CD3+、CD4+、CD8+比较,差异有统计学意义(P<0.05),但CD4+/CD8+比较差异无统计学意义(P>0.05)。结论:手足口病患儿存在细胞免疫功能低下,重症组和EV71阳性组尤其明显,T细胞亚群测定可作为判断手足口病患儿病情严重程度的指标。 Objective:To discuss the relationship between hand foot and mouth disease in children in T cell subpopulation and the severity of the disease.Methods:241 patients with hand foot and mouth disease were selected from June 2011 to July 2013.They were divided into 74 cases of the severe group,167 cases of the mild group;children with severe EV71 were divided into the positive group(47 cases) and EB71 into the negative group(27 cases).We used flow cytometry T cell subsets(CD3+,CD4+,CD8+)percentage and calculated CD4 +/CD8 + ratio,to compare with normal values.Results:In the mild group 167 cases of children patients with acute T cell subpopulations were consistent with the children of the same age normal reference levels.The mild group and the severe group in CD3+,CD4+,CD8+and CD4+/CD8+,and the difference was statistically significant(P<0.05);the EV71 positive group and EV71 negative group in CD3+,CD4+,CD8+,the difference was statistically significant(P<0.05),but the CD4 +/CD8 + difference was not statistically significant(P>0.05).Conclusion:Hand foot and mouth disease of children have cellular immune dysfunction,and the severe group and EV71 positive group are especially obvious.T cell subsets can be used in diagnosis of children with hand foot mouth disease severity index.
作者 刘辛燕
出处 《中国社区医师》 2015年第10期112-113,共2页 Chinese Community Doctors
关键词 手足口病 T细胞亚群 EV71 Hand foot and mouth disease T cell subsets EV71
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