摘要
目的:对比不同给药方案对转移性结肠癌(m CRC)的疗效。方法:收治m CRC患者87例,依据用药方案分为观察组44例和对照组43例,对照组被给予Capox方案治疗,观察组被给予Capox方案联合低剂量阿司匹林治疗,对比两组疗效。结果:两组OR分别为48.8%与54.5%,组间差异无统计学意义(P>0.05),两组DCR分别为67.4%与88.6%,组间统计差异有统计学意义(P<0.05);两组1年期存活率分别为55.8%与79.5%,3年期存活率分别为34.9%与61.4%,组间统计差异均有统计学意义(P<0.05);两组不良反应无明显差异。结论:m CRC患者采用Capox方案联合低剂量阿司匹林治疗,可有效增其疗效而不加重不良反应。
Objective:To explore the different dosing regimens for metastatic colorectal cancer(mCRC) effect.Methods:87 mCRC patients were selected.On the basis of regimen,they were divided into the observation group with 44 cases and the control group with 43 cases.The control group were given Capox regimen treatment,and the observation group were given the Capox regimen combined with low dose aspirin treatment.We compared the treatment effect.Results:OR of the two groups respectively was 48.8%and 54.5%,and there was no significant difference(P>0.05).DCR of the two groups respectively was 67.4% and 88.6%,and the difference was statistically significant(P<0.05).In the two group,1 year survival rate respectively was 55.8% and 79.5%;3 years survival rate respectively was 34.9% and 61.4% ;the difference was statistically significant(P<0.05).There was no significant difference between the two groups of adverse reaction.Conclusion:Capox regimen combined with low dose aspirin therapy in patients with mCRC can significantly increase the efficacy and not increase adverse reactions.
出处
《中国社区医师》
2015年第A01期64-65,共2页
Chinese Community Doctors
