摘要
抑郁症是一种常见的精神疾病。全球范围内,预计有3.5亿人患有抑郁症,重度抑郁症已成为世界范围内致残的第二大疾病,并给家庭和社会带来严重的经济负担。尽管最近在神经科学研究方面取得了很大进展,但抑郁症病理生理学基础上的神经生物学机制仍知之甚少。神经发生是新的神经元产生的过程,神经发生除维持正常的生理功能外,近几十年来研究发现,神经发生在抑郁症的病理生理学和症状学中起着重要作用。深入研究神经发生的调控机制,不仅可以阐明神经发生在抑郁症病因学中的作用,同时对理解治疗药物的药理学机制以及发现新药具有重要意义。因此,该综述对神经发生在抑郁症的作用及机制进行了讨论。
Depression is a kind of common mental illness.Currently,nearly 350 million people suffer from depression,and major depression has become the second common disabled disease in the worldwide,resulting in a heavy socioeconomic burden in families and societies.Despite recent advances in neuroscience research,the neurobiological mechanisms underlying the pathophysiology of depression remain poorly understood.Neurogenesis is a process of producing new neurons from neural stem cells.Besides maintaining normal physiological function,neurogenesis also plays a key role in pathophysiology and symptomatology for depression.In the past decades,extensive effort has been spent on the understanding of the functional significance of neurogenesis in the pathogenesis of depression,mechanisms of pharmacological treatment,and discovery of novel drug candidates for depression.This review discusses the role and mechanism of neurogenesis in depression.
作者
刘星
包金风
Liu Xing;Bao Jinfeng(Inner Mongolia Medical University,Hohhot 010110,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第6期1184-1192,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81541160)
内蒙古自然科学基金(批准号:2015MS0312)
内蒙古医科大学百万工程基金(批准号:YKD2014KJB002)资助的课题~~
