摘要
泛素化是蛋白质翻译后的一种重要修饰方式。通过泛素化,蛋白质被标记上多聚泛素化链,而被蛋白酶体所识别并导致其降解。细胞周期是细胞增殖的基础,泛素化介导的蛋白质降解在驱动真核生物细胞周期的有序运行中起着极其重要的作用。近年来的研究表明,泛素化是一个可逆的过程,去泛素化酶能够逆转泛素化过程而稳定蛋白质,并与细胞周期各时相的调控密切相关。因此,该文就去泛素化酶在细胞周期调控中的最新研究进展进行了综述。
Ubiquitination is an important modification of protein translation.Through ubiquitination,proteins are labeled with polyubiquitinated chains that are recognized by the proteasome and cause degradation.The cell cycle is the basis of cell proliferation,and ubiquitin-mediated protein degradation plays an extremely important role in driving the orderly operation of cell cycle in eukaryotes.In recent years,studies have shown that ubiquitination is a reversible process.Deubiquitinase can reverse the ubiquitination process and stabilize proteins,and are closely related to the regulation of cell cycle phases.Therefore,the recent advances of deubiquitinases in cell cycle regulation are reviewed.
作者
魏东
邓堂刚
叶茂
Wei Dong;Deng Tanggang;Ye Mao(College of Biology,Hunan University,Changsha 410082,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第6期1135-1143,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81672760)
湖南省重点研发计划(批准号:2018SK2128)
湖南省研究生科研创新项目资助的课题~~
