摘要
利用从螺旋藻中提取的γ 亚麻酸甲酯 (GLAME) ,分别制成含GLAME0 .2 5 %、0 .5 %、1%的饲料喂饲正常大鼠和高脂膳食喂养形成的高脂血症大鼠 ,连续 4周 ,测定血脂、肝脂及血浆和肝脏丙二醛 (MDA)含量。结果表明 :GLAME能显著降低正常大鼠和高脂血症大鼠血浆TC、TG、LDL C含量和AI ,升高HDL C含量和HDL C/TC ,能降低正常大鼠和高脂血症大鼠血浆和肝脏MDA含量及肝胆固醇含量 ,降低高脂血症大鼠肝指数 (肝重 /体重 ) ,但对正常大鼠的肝指数无明显影响。
The hyperlipemia model was established by feeding the rats with high fat diet. The hyperlipidemic rats were fed with the diet containing 0.25%,0.5%,1% gamma-linolenic acid methyl ester(GLAME), which was derived from Spirulina maxima for 4 weeks, then the plasma and liver lipid indexes were detected. The results showed that GLAME could significantly decrease levels of plasma total cholesterol(TC), triglycerides(TG), low density lipoprotein cholesterol(LDL-C) , MDA,atherosclerosis index(AI) and liver TC, MDA, and increase levels of high density lipoprotein cholesterol(HDL-C) in both normal and hyperlipidemic rats. GLAME decreased liver index(the ratio of liver weight and body weight) in hyperlipidemic rats, but had no significant effect in normal rats.
出处
《中国海洋药物》
CAS
CSCD
2003年第6期30-34,共5页
Chinese Journal of Marine Drugs
关键词
γ-亚麻酸甲酯(GLAME)
调血脂
抗氧化
gamma-linolenic acid methyl ester(GLAME)
hypolipidemic effect
antioxidant effect
