摘要
目的 探讨A族溶血性链球菌感染在抽动障碍发病中的作用。方法 采用抗DNA酶B微量法 ,测定 4 6例抽动障碍患者和 4 6名健康对照的抗DNA酶B抗体。结果 抽动障碍患者抗DNA酶B的几何平均滴度 ( 0 19U/L)高于健康对照 ( 0 12U/L ;t=2 17,P <0 0 5 ) ;抗DNA酶B的阳性率 ( 5 2 % ,2 4 / 4 6 )也高于健康对照组 ( 30 % ,14 / 4 6 ) ,差异有显著性 ( χ2 =4 4 8,OR =2 4 9,P <0 0 5 )。抽动障碍患者抗DNA酶B滴度与耶鲁抽动症整体严重度量表评分间呈正相关 (r=0 35 ,P <0 0 5 )。
Objective To explore the role of Group A streptococcal infection in children with tic disorders Methods Anti DNase B antibodies in 46 patients with tic disorders and 46 normal children were detected by Anti DNase B antibody microtitration test Results In children with tics, geometric mean of Anti DNase B antibody (0 19 U/L) was significantly higher than that in control subjects (0 12 U/L; t= 2 17, P< 0 05) The positive rate of Anti DNase B antibody (24/46) was significantly higher than normal children (14/46; χ 2=4 48, OR= 2 49, P< 0 05) In children with tics, a positive correlation between Anti DNase B antibody titers and severity of tic disorder was found ( r= 0 35, P< 0 05) Conclusion Group A streptococcal infection might be correlated to tic disorders
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2003年第4期231-233,共3页
Chinese Journal of Psychiatry
基金
浙江省温州市科学技术委员会基金资助项目(S2 0 0 0A16)
浙江省医学重点学科(神经病学)基金资助(970 15 )
