摘要
目的:研究大肠癌组织nm23-H_1的表达及其与淋巴结转移的关系.方法:应用免疫组化S-P法检测52例大肠癌标本中nm23-H_1的表达.结果:52例大肠癌原发瘤标本表达阳性率为96.1%(50/52),其中nm23-H_1高表达占59.6%(31/52).nm23-H_1低表达者19例(36.5%,19/52),包括有淋巴结转移者18例(94.7%,18/19).而有淋巴结转移的28例中,低表达者18例(64.2%,18/28).结论:大肠癌淋巴结转移与nm23-H_1表达水平呈负相关,表明nm23-H_1基因是肿瘤转移抑制基因之一.
Objective: To investigate the relationship between the expression of nm23 - H_(1) gene and lymph node metastasis in the tissue of colorectal carcinoma.Methods:The expression of nm23 ?H_(1) were examined by immunohistochemical technique in paraf-fin - embeded tissue specinmens of 52 cases with colorectal carcinoma. Positive expression were 50 cases (96.1 % , 50/52 ), in which high expression were 31 cases(59.6%, 13/52), low expression were 19 cases(36.5%, 19/52) in which lymph node meestasis were 18 cases(94.7% , 18/19). In 28 cases with lymph node metastasis, low expression were 18 cases(64.2% , 18/28) .Conclusion: An in-verse corrlation is observed between the expression level of nm23 - H_(1) and lymph node metastasis. It is showed that nm23 - H_(1) gene is a candidate supressor of tumor metastasis.
出处
《临床肿瘤学杂志》
CAS
1999年第2期1-2,共2页
Chinese Clinical Oncology
关键词
大肠癌
淋巴结转移
基因表达
免疫组化
肿瘤
Colorecteal carcinoma
Lymph node metastasis
nm-23_(H1)
Expression
