摘要
目的 :评价盐酸曲马多缓释片 (奇曼丁 )治疗中度以上肌肉骨骼系统慢性持续性疼痛的临床疗效与耐受性。方法 :在骨科门诊选择中度以上慢性非癌症性疼痛 ,应用NASIDs疼痛缓解不满意的成人病例共 4 0例 ,服用奇曼丁 ,根据疼痛控制程度和副反应调整剂量。总观察时间为 4周 ,受试者记录疼痛治疗手册 ,每周门诊随访 1次 ,医师检查后填写临床观察表。结果 :全部病例均完成试验 ,无失访和因不能耐受而退出者。服药前VSA值平均为 ( 6 8± 1 84 )分 ,服药后VSA值平均为 ( 1 0± 1 4 6 )分 ,两者经t检验 ,差异有显著性意义 (P <0 0 0 1)。平均疼痛缓解度为 ( 85 5± 5 35 ) % ,其中完全缓解和明显缓解占 77 5 %。不良反应 9例 ,总发生率为 2 2 5 % ,结论 :奇曼丁作为盐酸曲马多的缓释片 ,是一种长效中枢性镇痛剂 ,使用方便。在治疗肌肉骨骼系统的慢性疼痛方面具有优良的镇痛效果 ,副反应程度轻 ,有良好的耐受性 ,为骨科慢性疼痛的药物治疗提供了一种新的选择。
OBJECTIVE: To evaluate clinical efficacy and the tolerance of tramcontin on moderate chronic persistent pain in musculoskeletal system.METHODS: 40 adult cases with moderate chronic nontumorous pain and unsatisfied pain relief by NASIDs were chosen in orthopedic out-patient clinic.They were given tramcontin. The dosage was adjusted according to pain control level and the side-effect.The total observing time lasted for 4 weeks pain treatment condition of the testee were recorded.The testee were followed up once a week.Clinical observing table was filled in after examination by the doctors.RESULTS: All cases finished the tests. No one withdrew. The average value of VSA before and after taking the drug was 6 8±1 84 and 1 0±1 46 respectively. The difference had obvious significance after these two values were tested by 7 value ( P <0 001). The average pain relief rate was (85 5±5 3)%. Of those, complete and obvious pain relief was 77 5%, 9 cases with side.Effect,the total incidence was 22 5%.CONCLUSION: Tramcontin, as the slow-released tablet of tramadol hydrochloride, is a long acting central analgesic and convenient to use. It has best analgesic effect in chronic pain in musculoskeletal system. With slight side-effect and good tolerance, tramcontin is the new choice of the treatment of chronic pain in musculoskeletal systen.
出处
《中国医院用药评价与分析》
2003年第4期213-215,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
