摘要
目的 研究急性淋巴细胞性白血病 (ALL)中免疫表型的特点。方法 对 15 3例ALL应用流式细胞仪进行免疫表型分析。结果 ① 15 3例ALL中T淋巴细胞性ALL(T ALL) 2 2 .9%、B淋巴细胞性ALL(B ALL) 6 6 .7% ;ALL 1型 (L1) 37.9% ,ALL 2型 (L2 ) 5 6 .9%和ALL 3型 (L3 ) 5 .2 %。②ALL中髓系白血病细胞抗原 (My)阳性率33.98% ,表达单一抗原的最多为 5 9.6 % ,CD13阳性率最多为 2 3.5 % ,CD33为 2 0 .9%和CD14为 3.9% ;B ALL中My阳性率 38.6 % ,明显高于T ALL的 14 .3% ,P <0 .0 1;L2 中My阳性率为 4 2 .5 % ,明显高于L1的 2 5 .7% ,P <0 .0 1。③CD34阳性率 :B ALL中为 5 8.3% ,明显高于T ALL中的 4 0 % ,P <0 .0 5 ;但My阳性ALL和My阴性ALL中阳性率分别是 6 5 .4 %和 4 9.5 % ,差异无统计学意义 (P >0 .0 5 )。结论 ALL中髓系抗原和CD34的表达与白血病形态学分型 (FAB亚型 )
Objective To study the feature of immunophenotype in acute lymphoblastic leukemia(ALL).Methods 153 patients of ALL were immuno-phenotyped with flow cytometry.Results ①In 153 cases of ALL,T-ALL was 2.9%,B-ALL was 66.7%;ALL 1 37.9%,ALL 2 56.9%和ALL 3 5.2%.②In 153 ALL,the positive rate of myeloid antigen was 33.98%,the expression of single myeloid antigen was 59.6%; the positive rate of CD13 was 23.5%,CD33 was 20.9% and CD14 was 3.9%;the positive rate of myeloid antigen in B-ALL ( 38.6%) was significant higher than in T- ALL( 14.3%,P< 0.01);The positive rate of myeloid antigen in L 2( 42.5%) was significant higher than in ALL 1( 25.7%,P< 0.01)?③The positive rate of CD34 was 58.3% of B- ALL, significantly higher than 40% of T-ALL(P< 0.05);but the positive rate of CD34 in positive or negative myeloid antigen ALL was 65.4% and 49.5% respectively(P> 0.05).Conclusion The expression of myeloid antigen and CD34 in ALL was related to FAB and immune subtype.
出处
《临床荟萃》
CAS
北大核心
2003年第22期1276-1278,共3页
Clinical Focus
