摘要
重组蛋白药物在体内存留时间的长短 ,极大地影响到药物的使用剂量和治疗效果。防止多肽在体内迅速降解、延长半衰期成为蛋白质工程药物改造的重要课题之一。经过许多学者多年来的不懈研究 ,不少长效多肽药物已经上市 ,还有一些正在进行临床研究。综述了几种多肽药物常用的长效改造方法如化学修饰、基因融合、点突变以及药物制剂释放系统的改造。
The time of recombinant peptides medine remain in vivo effect the dosage and therapeutic effect extremely. So, it become one of important tasks that to reconstitute these drugs for prevention of rapid degradation and short half\|life.After many years unremitting efforts,a lot of long effect peptides medicine have been on the market or on clinical trial.To reach this goal,the following ways such as chemical modification,gene fusion,point mutaion and delivery systems revolution are reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
2003年第10期23-27,共5页
China Biotechnology
