摘要
目的 :探讨大肠癌细胞增殖、分化与肿瘤细胞耐药性之间的关系。方法 :收集大肠癌标本 51例 ,显微镜下观察肿瘤的分化情况 ,并用免疫组织化学ABC法检测肿瘤细胞增殖细胞核抗原 (PCNA)和P 糖蛋白 (P Glycoprotein ,P gp)的表达情况 ,分析肿瘤细胞增殖、分化与Pgp表达的关系。 结果 :不同类型和分化程度的肿瘤细胞PCNA和Pgp的表达不同 ,但是 ,它们相互之间无明显的相关性 (P >0 .0 5)。结论 :大肠癌细胞增殖。
Objective: To explore the correlation among pro liferation, differenti ation and the express of Pgp in colorectal carcinoma. Methods: A total of 51 cas es were studied.Both PCNA and Pgp were detected by immunohistochemistry staining ABC method. The differentiation of the cancer cells were observed by microscope . Results: There are obvious differences in the differentiation, proliferation an d the expression of Pgp in cancer cells,but there are no sinificatent correlatio n among them. Conclusion: There are no significantent correla tion among the dif ferentiation,proliferation and the multidrug resistance in colorectal carcinoma.
出处
《江苏大学学报（医学版）》
CAS
2003年第5期394-395,397,共3页
Journal of Jiangsu University：Medicine Edition
关键词
大肠癌
分化
增殖
PCNA
PGP
colorectal carcinoma
diffrentiation
prolifera tion
PCNA
Pgp
