摘要
为有效控制麻疹 ,甘肃省于 1999年 12月～ 2 0 0 0年 1月首次在天水、定西地区 7个县对 8月龄～ 14岁儿童开展了麻疹疫苗 (MV)初始强化免疫。为评价强化免疫血清学效果 ,对部分儿童在免疫前后采集双份血清标本 ,用酶联免疫吸附试验 (ELISA)检测麻疹IgG抗体。结果表明 :MV强化免疫前 <15岁儿童麻疹抗体阳性率平均仅为6 0 5 6 % ,几何平均倒数滴度 (GMRT)为 5 0 2 6 2 ;MV强化免疫后抗体阳性率为 91 5 8% ,GMRT为 16 0 9 90 ,抗体阳转或≥ 4倍增长率为 6 8 6 5 % ,高抗体 (≥ 1:32 0 0 )比例由 9 91%上升到 4 6 0 4 %。本次MV强化免疫的开展 ,有效地减少了易感儿童 。
For controlling measles effectively and understanding the serological efficacy of measles vaccine immunization campaign conducted in December 1999～January 2000 in seven counties of Tianshui and Dingxi Prefectures, the measles serum IgG of the vaccinated children aged from 8 months to 14 years was tested before and after immunization by the method of ELISA. The results showed that the measles serum IgG positive rate of children below 15 years old increased from 60 65% to 91 58%; GMRT increased from 502 62 to 1?609 90. Antibody increasing rate more than 4 folds was 68 65%, the percentage of high antibody level (1:3?200) increased from 9 91% to 46 04%. Immunization campaign can reduce the number of susceptible children, and exert a positive effect to prevent measles outbreak or prevalence.
出处
《中国计划免疫》
2003年第5期266-268,共3页
Chinese Journal of Vaccines and Immunization
