摘要
目的:探讨血管性痴呆(vasculardementia,VD)和阿尔茨海默病(Alzheimer'sdisease,AD)认知功能损害及临床特点的差异,为早期诊断老年期痴呆提供依据。方法:对35例VD患者与34例AD患者进行简易智能状态量表(MMSE)测查及临床特点作对比研究。结果:①MMSE总分VD组(17.4±6.0)高于AD组(14.3±5.3)(t=3.908,P=0.001),6项因子分VD组高于AD组(t=3.614～3.614,P<0.05～0.01),VD以记忆力和计算力减退为主。②VD组高血压史、脑卒中史、局灶性神经系统体征(n/%:27/77,32/93,31/90)明显高于AD组(n/%:10/29,0,0)(χ2=9.583,13.568,112.759,P<0.05)。③VD急性或亚急性起病、病程呈波动特点多见,AD多呈缓慢起病、进行性发展。结论:结合VD与AD认知功能损害程度及不同的临床特点有助于VD与AD的早期诊断及鉴别诊断。
AIM:To explore the differences of cognitive impairment and clinical feature s between vascular dementia(VD)and Alzheimer' s disease(AD)so as to assist the diagnosis for patients wi th senile dementia.METHODS:Thirty-five patients with VD and 34p atients with AD were e-valuated by mini-mental state exami nation(MMSE),and the clinical symptoms were compared between the t wo groups.RESULTS:①The average scores of MMSE were 17.4±6.0in the VD group,markedly higher than in the AD group.The scores of 6factors in the VD group were also higher than those of the AD g roup(t=2.614-3.614,P<0.05-0.01).The primary symptoms were the decli ned intelligence and calculation for the patients with VD.②The number of the patients with the hi story of stroke and hypertension and positiv e signs of focal nervous system in the VD group(n/%:27/77,32/93,31/90)were significantly higher than that of the AD group(n/%:10/29,0,0)(χ 2 =9.583,13.568,112.759,P<0.05).③The course of patients with acute or s ub-acute VD was a fluctuating process,but that of patients with ch ronic AD was a developmental process.
出处
《中国临床康复》
CSCD
2003年第28期3852-3853,共2页
Chinese Journal of Clinical Rehabilitation
关键词
血管性痴呆
阿尔茨海默病
认知功能
智能状态量表
MMSE
VD
AD
Combining the differences of cognitive impairment and clinical features are helpful for early diagnosis and early differentia l diagnosis of VD and AD.
