摘要
目的:探索脑活素对血管性痴呆患者智能状况的改善效果。方法:将29例符合血管性痴呆标准的患者分为对照组和治疗组。对照组用血塞通0.4g,治疗组在对照组的基础上加用脑活素20mL,10d为1个疗程,3年共6个疗程,其后分别采用中文版简易智能状态检查(MMSE)量表进行积分,用中国人修订韦氏成人量表(WAIS-RC)进行智力测验比较。结果:根据WAIS-RC测验结果,两组3年后知识(11.32±1.76比9.23±1.78)、领悟(13.19±1.85比11.24±2.12)、算术(10.18±1.32比8.63±1.25)、相似(9.46±0.68比7.56±0.98)、数字广度(10.12±0.69比8.68±0.97)、词汇(31.25±0.78比27.32±1.02)、数字符号(31.35±1.20比25.35±0.78)、填图(9.78±0.98比7.45±0.65)、图片排列(19.16±0.74比15.23±1.52)等项目比较,治疗组积分明显高于对照组(t=1.96～5.21,P<0.05或0.01)。治疗组治疗前后上述项目自身对照积分亦有显著提高(t=1.96～5.21,P<0.05或0.01)。结论:脑活素能有效抑制神经细胞的凋亡,减少脑功能的受累,治疗血管性痴呆,对老年群体的康复有一定的治疗作用。
AIM:To investigate the curative effect o f cerebrolysin in improving intelli-gence of vascular dementia(VD)patients.METHODS:Twenty-nine patients with VD were ra ndomly assigned to treat with Xuesaitong at a daily dose of 0.4g and cerebrolysin at a daily dose of20mL(treatment group)or Xuesaitong at a daily dose of 0.4g a lone(control group)for 10day as a course.The duration wa s three years for 6courses.To score using the Mini-men tal state examination(MMSE)of Chi-nese version and WAIS_RC were conducted after 3years.RESULTS:At the end of three years,according t o WAIS-RC examination,the scores of knowledge,comprehension,arithmetic,acquaintance,dig it span,vocabulary,figure,fill the d iagram and toy bricks were 11.32±1.76,13.19±1.85,10.18±1.32,9.46±0.68,10.12±0.69,31.25±0.78,31.35±1.20,9.78±0.98and 19.16±0.74in the treatment group,sig-nificantly higher than 9.23±1.78,11.24±2.12,8.63±1.25,7.56±0.98,8.68±0.97,27.32±1.02,25.35±0.78,7.45±0.65and15.23±1.52of the control group(t=1.96-5.21,P<0.05).Before and after treatment,there was a sign ificant difference in the treatment group(t=1.68-4.22,P<0.05or 0.01).
出处
《中国临床康复》
CSCD
2003年第28期3850-3851,共2页
Chinese Journal of Clinical Rehabilitation
关键词
脑活素
血管性痴呆
智能状态检查
MMSE
智力测验
Cerebrolysin is effective to inhibi t the apoptosis of nerve cells,and decrease the tiredness of brain function.It has a certain effe ct in treatment of vascular dementia and p lays a good role in the rehabilitatio n of old-age community.
