摘要
目的十全大补汤对D-半乳糖致衰老小鼠学习记忆能力及抗氧化作用的研究。方法连续给小鼠注射D-半乳糖6周,同时从第三周起给模型鼠灌胃十全大补汤,给药结束后,进行学习记忆行为测定,采血清测定超氧化歧化酶(SOD)、;丙二醛(MDA)含量。结果十全大补汤组小鼠的学习、记忆获得和记忆消退的错误次数明显少于衰老模型组(P<0.05);与模型组比较,十全大补汤组小鼠血清SOD活性显著性降低。结论十全大补汤能改善D-半乳糖致衰老小鼠的学习记忆能力,提高体内SOD活性,增强其对自由基的清除能力,抑制脂质过氧化作用。
Objective To study the learning memory and antioxidantion of Shiquandabu decoction to the model of mouse aging with the inducement of D-galactose. Methods In a row to the mouse injected D-galactose 6 weeks, while the third week of the mouse model of oral Shiquandabu decoction, after the end of the administration, to carry out learning memory and acts of determination, determination of serum taken superoxide dismutase （ SOD ）, ; malondialdehyde （MDA） content. Results Shiquandabu decoction mouse learning, memory access and faded memory error significantly less than the number of aging model group （ P 〈 0. 05 ） ; compared with the model group, Shiquandabu decoction mouse serum SOD activity significantly lower. Conclusion Shiquandabu decoction can improve the D-galactose-induced aging of learning and memory in mouse, raising SOD activity in the body, enhance its ability to remove free radicals and inhibiting lipid peroxidation.
出处
《中国实用医药》
2009年第23期52-54,共3页
China Practical Medicine
基金
广州市中西医结合立项研究课题(项目编号:2004A035)
关键词
十全大补汤
D-半乳糖
学习记忆
抗氧化
Shiquandabu decoction
D-galactose
Learning memory
Antioxidant
