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Toll样受体在介导免疫及炎症反应中的作用 被引量:4

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摘要 Toll样受体是近年发现的在天然免疫及炎症反应中起重要作用的一类跨膜受体,对Toll样受体的认识主要源自 对TLR2和TLR4在介导内毒素LPS信号转导中作用的研究。本文就Toll和Toll样受体的结构、成员、信号通路及其在免疫及 炎症反应中的作用作一综述。
出处 《国外医学(麻醉学与复苏分册)》 2003年第5期268-271,共4页 Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
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  • 1Shimazu R, Akashi S, Ogata H, etal. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med., 1999,189:1777-1782. 被引量:1
  • 2Ohashi K, Burkart V, Flohe S, et al. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol,2000,164:558-561. 被引量:1
  • 3Belvin MP, Anderson KV. A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rex Cell Dev Biol, 1996, 12: 393-416. 被引量:1
  • 4Lemaitre B, Nicolas E, Michaut L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 1996,86:973-983. 被引量:1
  • 5Hashimoto C, Hudson KL, Anderson KV. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell, 1988,52:269-279. 被引量:1
  • 6Morisato D, Anderson KV. Signaling pathways that establish the dorsal-ventral pattem of the Drosophila embryo. Annu Rev Genet,1995,29:371-399. 被引量:1
  • 7Rock FL, Hardiman G, Timans JC, et al. A family of hurtmn receptors structurally related to Drosophila Toll. Proc Nail Acad Sci U S A,1998,95:588-593. 被引量:1
  • 8Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 1997,388 : 394-397. 被引量:1
  • 9Schuster JM, Nelson PS. Toll receptors: an expanding role in our understanding of human disease. J Leukoc Biol,2000,67:767-773. 被引量:1
  • 10Buchanan SG, Gay NJ. Structural and functional diversity in the leucine-rich repeat family of proteins. Prog Biophys Mol Biol, 1996,65:1-44. 被引量:1

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