摘要
目的:评价酸枣仁油的用药安全性。方法:常规毒性实验和血液生化检查。结果:酸枣仁油对大小鼠均未测出LD50,家兔皮肤刺激实验未见急性毒性反应。大鼠的体重、血液学检查、血液生化学检查无显著性差异,大鼠的心、肝、脾、肺、肾、肾上腺、胸腺、睾丸、子宫、卵巢等器官肉眼观察及病理切片光镜检查,均未发现明显病理改变。豚鼠皮肤、兔眼睛及阴道局部应用,未见明显刺激反应。豚鼠皮肤未见过敏反应。结论:临床应用酸枣仁油并无毒性。
OBJECTIVE: To evaluate medinal safety of oil of spine date seed . METHODS: Acute toxicity test and blood biochemistry test were used. RESULTS: We did not get LD50 to mouse and rat, and no chronic toxicity to rabbit skin. The weight and blood index on rat were not remarkable from contral group, We did not find pathology difference on heart, liver, lung, kidney, adrenal gland, thymus, spermary, matrix, ovary etc by general view and pathology slice. No evidence irritation reaction had happened to guinea pig skin、rabbit eyes and part of cunt. We had not found hypersensitivity guinea pig skin. CONCLUSION: The seed oil of spine date is safe on medinal usage.
出处
《药学实践杂志》
CAS
2003年第5期283-286,共4页
Journal of Pharmaceutical Practice
