摘要
为探讨魔芋葡苷聚糖(KGM)复配银杏黄酮(FGb)后与单独KGM相比对大鼠脂质代谢紊乱的调节作用,在建立大鼠高脂血症模型的基础上,分组观察比较KGM和FGb复配物与KGM对大鼠血脂水平,抗氧化能力,肝脏组织形态等方面的影响,结果发现KGM和FGb复配物能显著抑制喂高脂高胆固醇饲料大鼠血清总胆固醇的低密度脂蛋白-胆固醇(LDL-C)和ApoB浓度,显著升高高密度脂蛋白-胆固醇(HDL-C)和ApoA1浓度,与单独KGM相比改善对TG代谢的影响。KGM和FGb复配物还能显著降低血清和肝脏丙二醛(MDA)含量,增强红细胞和肝脏超氧化物歧化酶(SOD)的活性,同时增强全血谷光甘肽还原酶(GSH-Px)活性,效果显著优于KGM。肝组织形态学观察显示,复配物与KGM对实验大鼠肝脏组织均有保护作用。可见复配适量FGb能改善KGM对实验大鼠的血脂调节效果,提高抗氧化能力,且对其肝脏有保护作用。
To elucidate the regulatory effects of combination of konjac glucomannan (KGM) and ginkgo flavonids (FGb) on hyperlipemia and to compare the different effects between combination and KGM. On the basis of establishing hyperlipidemia rat model, blood lipids, antioxidative capacity and liver tissues were investigated after 7-week feeding of different diets. The combination of KGM and FGb significantly reduced the serum TC, LDL-C, ApoB concentration and improved atherosclerotic indices, increased the HDL-C and ApoA-1 levels, and could make the serum TG level much lower than KGM could. The combination significantly decreased MDA content in both serum and liver, increased RBC and hepatic SOD activities and promoted the activity of GSH-Px as well, and these effects are much more superier to KGM. The morphologic observation showed that both the combination and KGM itself have protective role to liver tissues. Conclusion: The combination of KGM and FGb has better effects on decreasing the hypolipidemic rats' serum TG level and better ability of antioxidatipn than KGM, and also can protect the rats' liver tissues.
出处
《中山大学学报（自然科学版）》
CAS
CSCD
北大核心
2003年第A19期195-198,共4页
Acta Scientiarum Naturalium Universitatis Sunyatseni
基金
科技部攻关课题资助项目(99-010-01-13)
安徽省自然科学基金
关键词
魔芋葡苷聚糖
银杏黄酮
脂质代谢
抗氧化
肝脏组织
konjac glucomannan
ginkgo flavonids
lipid metabolism
antioxidation
liver tissues
