摘要
目的 探讨脊髓损伤 (spinalcordinjury ,SCI)对大鼠股骨生物力学和骨密度 (bonemineraldensi ty ,BMD)的影响。方法 将 40只 3月龄大鼠随机分为SCI组和对照组 ,SCI组于T10 椎体处完全切断脊髓 ,对照组仅行椎板切除术。于术后 3 ,6周分 2批处死动物进行股骨骨密度和生物力学测定。结果 术后 3周时SCI组大鼠股骨远端BMD较对照组显著下降 (P <0 .0 5 ) ;术后 6周时SCI组股骨近端BMD与对照组比较 ,下降差异显著 (P <0 .0 5 ) ;股骨远端BMD较对照组下降差异非常显著 (P <0 .0 1) ;股骨干BMD与对照组相比有降低趋势 ,但无统计学意义。术后 3周时股骨颈最大载荷、最大变形、结构刚度及能量吸收在 2组间差异均无统计学意义。术后 6周时最大变形、结构刚度和能量吸收均低于对照组 (P均 <0 .0 5 ) ,最大载荷低于对照组 ,差异具有极显著性意义 (P <0 .0 1)。结论 脊髓损伤后松质骨骨密度和生物力学性能的降低先于密质骨。脊髓损伤后 6周时SCI组股骨松质骨的骨密度及生物力学参数均显著低于对照组 ,脊髓损伤后
Objective To explore the effect of spina l cord injury(SCI) on the bone mineral density(BMD) and biomechanical properties o f femur in SD rats. Methods Forty 3-month-old rat s were randomly divided into the SCI group and control group with 20 in each gro up. Rats in the SCI group underwent spinal cord transection at the tenth thoraci c vertebrae. Rats in the control group underwent a sham procedure. Ten rats from each group were sacrificed at the time points of 3 weeks and 6 weeks after the operation, respectively. BMD measurement in different part of femur and test of biomechanical in femoral neck were performed. Results BMD of distal femur in SCI group was significantly lower than that in control group at 3 weeks postoperatively ( P <0.05).Significantly decreased BMD was d etected in proximal and distal femur in rats with SCI at 6 weeks in comparison w ith the controls ( P <0.05, P < 0.01 respectively). There was no signifi cant difference of the BMD in shaft of femur between the two groups at 3, 6 week s postoperatively. There was no difference in value of maximum load, maximum def ormation, energy absorption capacity and structural rigidity in femoral neck thr ough bending test at 3 weeks. However, there are significant decrease in value o f maximum load, maximum deformation, energy absorption capacity and structural r igidity in SCI group in comparison with the controls at 6 weeks( P <0.01, P <0.05, P <0.05, P <0.05, respectively). Conclusion Fall of BMD and decrease of biomechanical properties in cancellated bone is prior to that in compact bone in rats with SCI. Rats with SCI had a signific ant decrease of cancellated bone mass and biomechanical property of femoral head at 6 weeks after injury and it culd be used as the osteoporosis models followin g SCI.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2003年第9期524-526,共3页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
脊髓损伤
股骨
生物力学
骨密度
骨质疏松
Spinal cord injury
Bone mineral density
Biomechanical
Osteoporosis
Rats
