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整合素连接激酶与肾脏疾病 被引量:3

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摘要 整合素连接激酶 (integrin linkedkinase,ILK)是一种丝氨酸 /苏氨酸蛋白激酶 ,可以同整合素b1、b3亚基胞浆域结合 ,参与多种信号传导通路 ,包括整合素、生长因子及Wnt信号传导通路 ,在调节细胞粘附、凋亡、铺展、迁移、生长、细胞周期、基质积聚、肿瘤形成等过程中起重要作用 ,与肾脏疾病的发生过程相关。
作者 曾莉 黄颂敏
出处 《国外医学(泌尿系统分册)》 2003年第5期606-608,共3页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
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参考文献24

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同被引文献48

  • 1Marotta A,Parhar K,Owen D,et al.Characterisation of integrin-linked kinase signalling in sporadic human colon cancer[J].Br J Cancer,2003,88(11):1 755~1 762. 被引量:1
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  • 7Persad S,Attwell S,Gray V,et al.Inhibition of integrinlinked kinase (ILK) suppresses activation of proteinkinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):3 207-3 212. 被引量:1
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  • 9Tan C,Costello P,Sanghera J,et al.Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the Ecadherin repressor,snail,in APC-/-human colon carcinoma cells[J].Oncogene,2001,20(1):133~140. 被引量:1
  • 10Gruet-Hennequart S,Maubant S,Luis J, et al.alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells[J].Oncogene.2003,22( 11): 1688-702. 被引量:1

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