摘要
目的 :评价格拉斯琼对子宫切除术后恶心呕吐的影响。方法 :将 48例ASAⅠ～Ⅱ拟在持硬麻醉下行子宫切除的病人随机分为两组 ,格拉斯琼组 (G组 ,n =2 4)及对照组 (C组 ,n =2 4)。两组病人麻醉及手术方式相 ,G组于术毕静注格拉斯琼 3mg ,C组则行空白对照。术后无恶心呕吐或仅有恶心且不需加用其它止吐药为有效。结果 :术后 0～ 3小时 ,G组有效率为 87 5 %、C组为 5 8 4 %;术后 3～ 2 4小时 ,G组为 83%、C组为 6 2 5 %;术后 2 4～ 48小时 ,G组为 70 %、C组为 6 6 %。结论 :术毕静注格拉斯琼对术后 2 4小时内发生的恶心呕吐有良好的控制作用 ,2 4小时后其作用减弱。
Object: To evaluate the efficacy of granisetron for reducing postoperative nausea and vomiting (PONV) in patients who had received total hysterectomy under epidural anesthesia.Methods: 48 patients,ASA physical status Ⅰ～Ⅱ,scheduled for total hysterectomy under epidural anesthesia were randomly divided into two groups(n=24 each);Granisetron group (G group) and Control group( C group).Standard epidural anesthetic and operative technique were used in each case.At the end of operation,granisetron 3mg and the same dosage of saline were administrated intravenously to G group and C group patients respectively.The incidence of complete response,define as no PONV or retching only but not need another medication to rescue,was recorded.Results: The incidences of complete response at 0～3h and 3～24h after surgery were 87.5%,83% in G group and 58.4%,62.5% in C group, respectively.There was a significant difference in the two groups (P<0.01,P<0.05).While the incidence at 24～48h after surgery were 70% and 66% in two groups,respectively,without significant difference(P>0.05).Conclusion: Our results suggest that administration of granisetron by intravenous at the end of operation may be effective for reducing PONV within 24 hours after total hysterectomy.
出处
《四川肿瘤防治》
2003年第3期158-160,共3页
Sichuan Journal of Cancer Control
