摘要
目的 :探讨胆囊内胆汁粘度 (BV)和胆汁成分 (BI)对胆石形成的影响。方法 :对正常人 ,胆囊炎、胆石症病人以及正常兔、高胆固醇成石兔、成石 +中药兔BV的测定 ,探讨胆囊内BV对胆石形成的影响。结果 :同一切变率下 ,胆石症组BV最高 ,与其他两组比较差异显著 (P <0 .0 5 ) ;高胆固醇成石兔成石率达 90 % ,加中药组则降为11% ,对照组为零 ;成石兔胆汁酸、磷脂减少 ,胆固醇增高 ,而中药组胆汁酸、磷脂增加 ,胆固醇降低 ,两组相比有显著差异 (P <0 .0 1) ;成石兔BV显著高于其他两组 (P <0 .0 1)。结论 :胆石形成与胆囊内BV增高有关 ;中药在降低BV的同时起到了调整BI比例的作用 ,中药可能降低胆囊内BV 。
Objective: Our aim was to investigate the effects of bile viscosity(BV)and bile ingredients(BI) on stone formation in gallbladder. Methods: We examined BV and BI in healthy subjects, patients with cholecystitis and cholelithiasis, control rabbits, and experimental rabbits with cholecystitis. Results: In patients and experimental rabbits, BV in gallbladder stone group were higher than that in control groups with the same shearing rate(P<0.05).Gall-stone formation rate in rabbits, reached 90% when induced by cholesterol, and decreased to 11% when treated with Chinese herbs. Gall-stone rabbits showed lower biliary acid, lower phospholipid, and higher cholesterol than those treated with Chinese herbs(P<0.01). Conclusion: Gall-stone formation was closely related with increased BV in gallbladder. Chinese herbs might reduce the incidence of cholelithiasis by decreasing BV and changing BI in gallbladder.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2003年第5期460-461,共2页
Journal of China Medical University
基金
辽宁省自然科学基金资助项目 (95 2 2 0 8)
关键词
胆石形成
胆汁粘度
胆汁成分
中药治疗
gall-stone formation
bile viscosity
bile ingredient
herb treatment
