摘要
目的 研究黄芪多糖对脾虚水湿不化大鼠抗疲劳能力的影响。方法 高脂低蛋白加力竭游泳法建立脾虚水湿不化大鼠模型,给与高、中、低剂量黄芪多糖灌胃,检测负重力竭游泳时间、甘油三酯(TG)、胆固醇(CHOL)、低密度脂蛋白(LDL)、血尿素(UREA)、血清丙二醛(MDA)水平。结果 与模型对照组比,黄芪多糖组负重力竭游泳时间延长(P<0.01),血清TG、CHOL、LDL及UREA水平降低(P<0.05,P<0.01),血清MDA水平降低(P<0.05)。结论 黄芪多糖可有效改善脾虚水湿不化大鼠疲劳状况。
Objective To investigate the effects of Astragalus polysaccharides(APS)on anti-fatigue function of rats with dampness stagnancy due to spleen deficiency syndrome.Methods The rat model with dampness stagnancy due to spleen deficiency was induced by the high fat and low protein diet and exhaustive swimming method.The model rats were administrated APS.The swimming time,triglyceride(TG),cholesterol(CHOL),low density lipoprotein(LDL),blood urea(UREA),and malondiadehyde(MDA)were tested.Results Compared with the model group,the exhausted swimming time increased(P<0.01),the level of TG,CHOL,LDL,and UREA decreased(P<0.05,P<0.01),and MDA level decreased(P<0.05).Conclusion APS can attenuate the fatigue condition of rats with dampness stagnancy due to spleen deficiency,and exert their functions of invigorating spleen and removing dampness.
作者
赵文晓
李军山
张亚楠
王彦芳
王世军
ZHAO Wen-xiao;LI Jun-shan;ZHANG Ya-nan;WANG Yan-fang;WANG Shi-jun(Shandong Traditional Chinese Medicine,Ji'nan 250355,China)
出处
《时珍国医国药》
CAS
CSCD
北大核心
2019年第6期1320-1321,共2页
Lishizhen Medicine and Materia Medica Research
基金
山东省自然科学基金(ZR2016HM66)
山东省中医药科技发展计划项目(2017-003)
大学生科研训练(SRT)计划(2016053)
关键词
黄芪多糖
脾虚水湿不化
抗疲劳
Astragalus polysaccharides
Dampness stagnancy due to spleen deficiency
Anti-fatigue
