摘要
目的分析肺癌患者脉管内癌栓(intravascular cancer embolus,ICE)与表皮生长因子受体(epidermal growth factor receptor,EGFR)、核苷酸切除修复交叉互补基因-1(excision repair-cross complementing-1,ERCC1)和c-Met表达的关系以及对疾病预后的影响。方法采用免疫组织化学法检测EGFR、ERCC1和c-Met在128例肺癌组织(52例脉管癌栓,76例无脉管癌栓组织)及其癌旁组织中的表达情况,并分析脉管癌栓患者术后1年和3年生存率的差异。结果肺癌组织中EGFR和c-Met阳性表达高于癌旁组织,ERCC1低于癌旁组织(均P<0.05)。脉管癌栓阳性组中EGFR和c-Met阳性表达率高于脉管癌栓阴性组,ERCC1表达率低于脉管癌栓阴性组(均P<0.05)。肺癌脉管癌栓组织中,ERCC1阳性表达与EGFR阳性表达、c-Met阳性表达均呈负相关(r=-0.475,P=0.037;r=-0.513,P=0.024);EGFR阳性表达与c-Met阳性表达呈正相关(r=0.466,P=0.041)。脉管癌栓阴性患者术后1年和3年生存率均高于阳性患者(85.5%vs 67.3%,73.7%vs 34.6%;均P<0.05)。结论在肺癌脉管癌栓患者组织中EGFR和c-Met的表达升高,而ERCC1表达降低,与患者的预后密切关联。
Objective To analyze the expression of epidermal growth factor receptor(EGFR),excision repair-cross complementing-1(ERCC1)and c-Met in lung cancer with intravascular cancer embolus(ICE)and their relation with the prognosis of patients.Methods The expression of EGFR,ERCC1 and c-Met in 128 lung cancer tissues(52 cases of ICE and 76 cases of non-ICE)and para-carcinoma tissues were detected.The 1-and 3-year survival rates in ICE positive and negative patients were analyzed.Results The expressions of EGFR and c-Met in lung cancer tissues were significantly higher than those in para-carcinoma tissues,whereas the ERCC1 expression in lung cahcer tissue was significantly lower(all P<0.05).The expression rates of EGFR and c-Met in ICE positive patients were higher than those in ICE negative patients,and expression rate of ERCC1 in ICE positive patients was lower than that in ICE negative patients(all P<0.05).In lung cancer tissues,ERCC1 expression was negatively correlated with the expression of EGFR and c-Met(r=-0.475,P=0.037;r=-0.513,P=0.024).EGFR expression was positively correlated with c-Met expression(r=0.466,P=0.041).The 1-and 3-year survival rates of ICE negative patients were significantly higher than those of ICE positive patients(85.5%vs 67.3%,73.7%vs 34.6%;both P<0.05).Conclusion The expressions of EGFR and c-Met are increased and ERCC1 expression is decreased in lung cancer with ICE,which is closely related to the prognosis of patients.
作者
姚源山
沈海波
Yao Yuanshan;Shen Haibo(Department of Thoracic Surgery,Ningbo Second Hospital,Ningbo 315000,China)Corresponding to:Shen Haibo,E-mail:shbfly@163.com)
出处
《实用肿瘤杂志》
CAS
2019年第5期441-444,共4页
Journal of Practical Oncology
