摘要
目的探讨血清中异常凝血酶原(des-γ-carboxy prothrombin,DCP)、磷脂酰肌醇蛋白聚糖-3(glypican-3,GPC3)和热休克蛋白70(heat shock protein 70,HSP70)3种肿瘤标志物在甲胎蛋白(alpha-fetoprotein,AFP)阴性原发性肝癌(primary liver carcinoma,PLC)中的诊断价值及联合检测的意义。方法收集AFP阴性PLC 48例患者,良性肝病40例,健康体检者40例为对照组。检测血清中DCP、GPC3和HSP70的浓度,并进行比较。结果 AFP阴性PLC组患者血清DCP、GPC3和HSP70水平及阳性率均高于良性肝病组及对照组,差异均具有统计学意义(均P<0.05)。DCP、GPC3和HSP70联合检测对AFP阴性PLC诊断的敏感度、特异度及准确度均高于单独检测(均P<0.05)。结论 DCP、GPC3和HSP70联合检测对AFP阴性PLC的诊断具有重要价值。
Objective To investigate the combined determination of serum des-γ-carboxy prothrombin( DCP),glypican-3( GPC3) and heat shock protein-70( HSP70) in the diagnosis of alpha-fetoprotein( AFP) negative primary liver carcinoma( PLC). Methods Forty-eight patients with AFP negative PLC,40 patients with benign liver disease and 40 healthy subjects( control proup) were recruited in the study. Serum DCP,GPC3 and HSP70 levels were detected and analyzed in all subjects. Results The levels and positive rates of serum DCP,GPC3 and HSP70 in AFP-negative PLC group were higher than those in benign liver disease group or control group( P < 0. 05). The sensitivity,specificity and diagnosis accuracy of combined determination of DCP,GPC3 and HSP70 were higher than those of any single marker( P < 0. 05).Conclusion Combined determination of serum DCP,GPC3 and HSP70 can be used for the diagnosis of AFP negative PLC.
出处
《实用肿瘤杂志》
CAS
2017年第2期133-136,共4页
Journal of Practical Oncology
基金
浙江省卫生厅科研基金(2013KYB143)
