摘要
[目的]观察补中益气汤联合化疗治疗胃癌术后疗效。[方法]使用随机平行对照方法,将60例住院患者按就诊顺序号随机分两组。对照组30例常规化疗,第1天静脉滴注奥沙利铂130mg/m^2,第1～5天静脉滴注亚叶酸钙100mg/m^2,氟尿嘧啶500mg/m^2。治疗组30例补中益气汤(党参、天麦冬各10g,半枝莲、黄芪各个30g,陈皮、白花蛇舌草各10g、茯苓20g,赤芍10g,白术15g,枳壳30g,柴胡、当归、半夏、桔梗各10g,薏苡仁生30g;乏力明显加黄芪至50g;舌质紫暗瘀斑加丹参10g,郁金12g;胃脘气滞胀满加枳壳、佛手、乌药各10g;大便秘结加大黄炒5g,火麻仁20g;胃脘疼痛明显加三七6g,延胡索12g;脾虚便溏加桂枝5g,肉豆蔻5g,姜炮3g;纳食欠佳加神曲20g;泛酸烧灼恶心加吴茱萸淡2g,川黄连3g,海螵蛸20g),1剂/d,水煎300mL,早晚分服;化疗同对照组。连续治疗4周为1疗程。观测临床表现、中医症状总积分、生存质量评分、不良反应。连续治疗6疗程,判定疗效。[结果]治疗组显效10例,有效15例,无效5例,总有效率83.33%;对照组显效17例,有效11例,无效14例,总有效率53.33%;治疗组疗效优于对照组(P<0.05)。中医症状总积分、生存质量评分两组均有明显改善(P<0.05),治疗组改善优于对照组(P<0.05)。不良反应发生率治疗组低于对照组(P<0.05)。[结论]补中益气汤联合化疗治疗胃癌术后,疗效满意,无严重不良反应,值得推广。
[Objective]To observe the curative effect of Bu Zhong Yi Qi Decoction Combined with chemotherapy in the treatment of gastric cancer.[Methods]Using random parallel control method,60 hospitalized patients were randomly divided into two groups according to the order number.In the control group,30 cases were treated with conventional chemotherapy,first days of intravenous infusion of oxaliplatin130 mg/m^2,and first to 5 days of intravenous infusion of calcium folate 100 mg/m^2 and fluorouracil 500 mg/m^2.In the treatment group,30 cases of Buzhong Yiqi Decoction(Codonopsis,Rhizoma Ophiopogon,10 g,rhizoma and Astragalus 30 g,10 g,Poria 20 g,10 g of Radix Paeoniae Rubra,15 g of Radix Paeoniae Alba,Fructus trifoliate 15 g,Fructus aurantii,Radix Bupleuri,Radix Angelicae,Rhizoma Pinellia and Platycodon grandiflorum 30 g;fatigue of Radix Astragali to 50 g,lingual purple dark ecchymosis plus Salvia 10 g,tulip 12 G;stomach qi stagnation filled with Fructus aurantii,trifoliate,Buddhist and black medicine each 10 g;the constipation of the stool knot enlarges the Yellow stir fry 5 g,the fire hemp 20 g;the epigastric pain is obviously added 37 6 G,the Corydalis 12 g;the spleen asthenia loose stool plus cinnamon branch 5 g,the nutmeg 5 g,the ginger 3 G;the nausea and the Shen Qu 20 g;pantothenic acid burning nausea and the 2 g dogwood,the Sichuan Rhizoma Coptidis 3 g,the sea cuttlebone,the sea cuttlebone,1 doses/d,decocted 300 mL,sooner or later divided;chemotherapy with the control group.Continuous treatment for 4 weeks was the 1 course of treatment.Clinical symptoms,symptom scores,quality of life scores and adverse reactions were observed.The 6 course of treatment was continuously treated to determine the curative effect.[Results]the treatment group effective 10 cases,effective 15 cases,invalid 5 cases,total effective rate 83.33%,the control group 17 cases,effective 11 cases,invalid 14 cases,total effective 53.33%,the treatment group was better than the control group(P<0.05).TCM symptom scores and quality of life scores improved
作者
麦柳芳
MAI Liufang(Department of oncology,Jinshazhou hospital,Guangzhou University of Chinese Medicine,Guangzhou 510168,China)
出处
《实用中医内科杂志》
2019年第1期36-39,共4页
Journal of Practical Traditional Chinese Internal Medicine
关键词
胃癌
补中益气汤
化疗
奥沙利铂
亚叶酸钙
氟尿嘧啶
中医症状总积分
生存质量评分
不良反应
中药复方
中西医结合治疗
随机平行对照研究
Gastric cancer
Buzhong Yiqi Decoction
Chemotherapy
Oxaliplatin
Calcium leucovorin
Fluorouracil
Total score of TCM symptoms
Quality of life score
Adverse reactions
Traditional Chinese medicine compound
Integrated Chinese and Western medicine treatment
