摘要
目的探讨彩超在孕11~13^(+6)周筛查中的应用。方法选取2012年6月至2015年6月在我院进行检查的孕11~13^(+6)周孕妇3 000名为研究对象。超声检测胎儿颈项部透明层厚度(NT)、鼻骨(NB)是否缺失、三尖瓣反流(TR)和静脉导管(DV)血流反向情况;同时对孕妇血清β-人绒毛膜促性腺激素(β-HCG)及胎盘与蜕膜产生的大分子糖蛋白A(PAPP-A)浓度进行测定,计算风险值,对筛查出的高风险孕妇进行绒毛活检,分析染色体异常胎儿的超声特点。结果本研究共筛查3 000名,正常核型2 987名胎儿中,活产儿2 955名;高风险150例,其中核型异常13例,21-三体7例,18-三体2例,45X0 3例,13-三体1例。38例先天性心脏病,核型异常组TR发生率高于核型正常组(χ~2=14.073,p<0.05);核型异常组DV反向a波发生率高于核型正常组(X^2=15.164,P<0.05)。结论孕11~13^(+6)周联合多项超声标记物联合筛查可增加胎儿染色体异常的检出率,且多个超声指标与胎儿心脏异常有关,值得临床广泛推广和应用。
Objective To investigate the applications of application of ultrasound screening in 11-13+6 weeks of pregnancy. Methods A total of 3 000 cases of pregnant women at 11-13+6 weeks in our hospital from June 2012 to June 2015 were collected, all women underwent ultrasound scan to measure fetal NT , nasal bone, ductus venosus blood flow, tricuspid blood flow, at the same time maternal serum free β-HCG and PAPP-A as part of screening for chromosomal abnormalities. Use the software to calculate the risk value of pregnant women. Screen high-risk pregnant women villus biopsy, and analyze the ultrasound features of fetal chromosomal abnormalities. Results Three thousand cases of pregnant women were detected, including 2 987 normal cases, 2 955 with live births; 150 with high risk, of which there were 7 with trisomy 21, 1 with trisomy 13, 2 with trisomy 18, 3 with Turner syndrome; 1 case with Patau syndrome, 38 with congenital heart disease. The rates of tricuspid regurgitation and abnormal ductus venosus blood flow pattern were higher in the abnormal karyotype group than those in the normal karyotype group (χ2=14.073, P<0.05;χ2=15.164, P<0.05). Conclusion Combined screening test has high chromosomal abnormalities detection rate at 11-13+6 weeks of gestation, and plurality of ultrasonic index and fetal heart abnormalities. It is worthy of wider promo-tion and application.
出处
《实用医学影像杂志》
2015年第6期461-464,共4页
Journal of Practical Medical Imaging
基金
福建省宁德市科学技术计划项目(20120037)
关键词
超声检查
妊娠
染色体
Ultrasonography
Pregnancy
Chromosomes
