摘要
目的研究非小细胞肺癌患者化疗相关呕吐(CIV)前驱症状的筛选及其化疗相关呕吐的影响。方法选择224例肺癌患者,分析患者的CIV前驱症状,用Logistic回归分析得出与CIV发生最相关的前驱症状;选择144例肺癌患者,对患者的前驱症状进行干预,对观察组和对照组患者的CIV的发生情况以及前驱症状发生率进行比较。结果224例患者中CIV发生率为64.29%,Logistic回归分析结果显示,便秘、呃逆、恶心、失眠以及食欲减退均与CIV的发生率存在明显的相关性。观察组患者的CIV发生率为30.56%,对照组患者的CIV发生率为51.39%,差异具有统计学意义(P<0.05)。结论 CIV前驱症状与CIV的发生率有密切的相关性,在化疗过程中,对患者的前驱症状进行及时的干预可以有效降低CIV的发生率。
Objective To explore the prodrome and its effect on non-small cell lung cancer patients with chemotherapyrelated vomiting. Methods The prodrome of chemotherapy-related vomiting( CIV) of 224 lung cancer patients were analyzed,Logistic regression analysis was used to conclude the relevant prodrome of CIV; 144 cases of lung cancer received interventions in prodromal symptoms. Incidence of CIV and prodrome in the observation group and the control group were compared. Results CIV incidence rates of 224 patients were 64. 29%,the Logistic regression analysis showed that constipation,hiccups,nausea,insomnia and loss of appetite were closely related to the incidence of CIV. CIV incidence rate of the observation group was30. 11%,and that of the control group was 51. 02%. There had significant difference( P < 0. 05). Conclusion CIV prodrome and the CIV incidence have close relationship,and timely intervention of prodrome of CIV can effectively reduce the incidence of CIV during chemotherapy.
出处
《实用癌症杂志》
2015年第9期1302-1304,1316,共4页
The Practical Journal of Cancer
关键词
非小细胞肺癌
化疗
呕吐
前驱症状
Non-small cell lung cancer
Chemotherapy
Vomiting
Prodrome
