摘要
目的 探讨肺癌患者化疗相关性呕吐（CIV）与CIV前驱症状的关系.方法 选择250例肺癌患者分析CIV的前驱症状,采用多因素Logistic回归分析定义CIV最相关的前驱症状;选择157例患者对CIV前驱症状进行药物干预,比较干预组与未干预组前驱症状变化及CIV的发生情况.结果 在分析前驱症状的250例患者中,CIV发生率为67.2％.Logistic多因素分析结果显示,恶心、便秘、失眠、呃逆和食欲减退与CIV有关（均P＜0.05）.在观察的20个前驱症状中,较常见的症状为恶心、食欲减退、味觉改变、便秘、腹胀、胃胀和失眠,其发生率分别为72.0％、68.4％、48.8％、45.6％、45.6％、40.4％和40.0％.干预组在干预前、后,除呃逆外,各症状的发生率差异均有统计学意义（均P＜0.05）.干预组CIV发生率为30.0％,未干预组为50.6％,差异有统计学意义（P＜0.05）.结论 CIV的发生与CIV前驱症状关系密切,在化疗过程中及时干预CIV前驱症状可以降低CIV的发生率.
Objective To explore prodromes of chemotherapy-induced vomiting （CIV） and their association with CIV in lung cancer patients.Methods The prodromes of CIV in 250 lung cancer patients were analyzed.Logistic regression was used to determine the symptoms most likely correlated with CIV.One hundred fifty-seven patients received medical interventions.The development of correlative symptoms and occurrence of CIV between the intervention and non-intervention groups was analyzed.Results Among the 250 patients with the prodromes of CIV,the incidence rate of CIV was 67.2％.Logistic regression indicated that nausea,constipation,insomnia,hiccups,anorexia,and history of drinking were correlated with CIV （P ＜0.05 for all）.Among the 20 symptoms observed in this study,the incidence rates of relatively common symptoms were nausea （72.0％）,anorexia （68.4％）,taste changes （48.8％）,constipation （45.6％）,abdominal distension （45.6％）,stomach distension （40.4％）,and insomnia （40.0％）.The incidence rats of all symptoms except hiccups before and after intervention had significant difference （P ＜ 0.05 for all）.The incidence rates of CIV were 30.0％ in the intervention group and 50.6％ in the non-intervention group,with a significant difference between the two groups （P =0.009）.Conclusions Prodromes of CIV are closely related to the occurrence of CIV.Timely intervention for prodromes of CIV can reduce the incidence rate of CIV during chemotherapy in lung cancer patients.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2014年第7期511-515,共5页
Chinese Journal of Oncology
基金
天津市抗癌重大专项攻关计划（12ZCDSY15600）
关键词
肺癌
抗肿瘤联合化疗方案
呕吐
前驱症状
干预
Lung neoplasms
Antineoplastic combined chemotherapy protocols
Vomiting
Predictive symptoms
Interventions
