摘要
目的比较单纯睾丸切除与睾丸切除后联合最大雄激素阻断(maximum androgen blockade,MAB)治疗中晚期前列腺癌的临床疗效。方法将38例中晚期前列腺癌患者划分为两组。第一组为单纯睾丸切除治疗,共17例;第二组为睾丸切除加最大雄激素阻断(MAB)治疗,共21例,比较两组患者的血清前列腺特异性抗原(PSA)、尿流率、前列腺大小及生存时间和质量。结果睾丸切除联合最大雄激素阻断组治疗后患者的生活质量明显优于单纯睾丸切除治疗组;而且两组在治疗12个月后,尿流率较治疗前均显著增高,血清PSA水平均显著降低,前列腺体积均明显缩小,睾丸切除联合最大雄激素阻断疗法降低血清中PSA水平效果更佳。结论睾丸切除联合最大雄激素阻断治疗中晚期前列腺癌,不仅可延长患者生存时间,还可以提高患者生存质量。
Objective To compare the clinical efficacy between orchiectomy and orchiectomy combined with maximum androgen blockade( MAB) in the treatment of advanced prostate cancer. Methods 38 patients with advanced prostate cancer,according to the specific conditions,were divided into2 groups. The first group recceived orchiectomy only,with 17 cases; the second group recceived orchiectomy plus MAB therapy,with 21 cases,serum prostate-specific antigen( PSA),urinary rates,prostate size,and survival time and quality between the 2 groups were compared. Results After removal of the testicles,MAB group presented better quality of life and survival rate than orchiectomy group; both group presented better improvement in urinary flow rate,serum PSA level and volume of prostate,the MAB group had better effect in reducing the level of PSA. Conclusion Orchidectomy combined with MAB for advanced prostate cancer can improve survival period and quality of life for patients.
出处
《实用癌症杂志》
2015年第1期118-120,共3页
The Practical Journal of Cancer
关键词
前列腺癌
睾丸切除
最大雄性激素阻断
Prostate cancer
Orchiectomy
Maximum androgen blockade(MAB)
