摘要
目的探讨基质金属蛋白酶-9(MMP-9)与血管内皮生长因子(VEGF)在肾癌组织中的表达及其临床诊断价值。方法选择86例肾癌患者作为观察组,选择同期自愿参加的20例健康者作为对照组。采用免疫组织化学法,检测肾组织中MMP-9与VEGF的表达情况。结果观察组MMP-9与VEGF阳性率明显高于对照组,差异均有统计学意义(P<0.05);MMP-9和VEGF在不同临床分期及不同病理分级中的表达,差异有统计学意义(P<0.05)。结论 MMP-9和VEGF与肾细胞癌发生发展有关,可作为临床诊断肾细胞癌的生物学指标。
Objective To discuss the expression of matrix metalloproteinase-9 ( MMP-9 ) and vascular endothelial growth factor ( VEGF) in renal cell carcinoma and its clinical diagnostic value .Methods 86 cases of renal cell carcinoma pa-tients was the observation group ,20 healthy persons selected to participate in voluntary was the control group .Expression of MMP-9 and VEGF in renal tissue was detected using immunohistochemical method .Results The positive rates of MMP-9 and VEGF in the observation group were significantly higher than those of the control group ,the differences were statistically significant ( P<0.05).The expression of MMP-9 and VEGF in different clinical stages and different pathological grading ,the difference was sta-tistically significant (P<0.05).Conclusion MMP-9 and VEGF are related with occurrence and development of renal cell car-cinoma,and they can be used as a biological marker in clinical diagnosis of renal cell carcinoma .
出处
《实用癌症杂志》
2014年第8期903-904,共2页
The Practical Journal of Cancer
关键词
MMP-9
VEGF
肾细胞癌
诊断价值
Matrix metalloproteinase-9 (MMP-9)
Vascular endothelial growth factor (VEGF)
Renal cell carcinoma ( RCC)
Clinical diagnostic value
