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MMP-2及MMP-9联合检测在脑胶质瘤中的诊断价值 被引量:3

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摘要 目前,颅内最常见的恶性肿瘤是胶质瘤,该病的特点是其对人脑的侵袭性生长,由于其界限与正常脑组织相比不清晰,手术切除较困难,患者预后差。在脑胶质瘤漫长而复杂的侵袭性生长过程中,基质金属蛋白酶(matrix-metallo-proteinase,MMPs)起着关键性的作用。MMPs由结缔组织细胞分泌而成,依靠蛋白酶家族ZN2+,降解细胞基底膜(ECM)和外基质,对肿瘤细胞的侵袭和转移有促进作用。笔者通过对120例脑胶质瘤标本和同期自愿参加的80例健康者采用免疫组织化学方法检测MMP-2及MMP-9的表达情况,分析其对脑胶质瘤的诊断价值。
出处 《中国实验诊断学》 2014年第2期205-206,共2页 Chinese Journal of Laboratory Diagnosis
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