摘要
目的评价晚期胃癌患者外周血中的TS(胸腺合成酶)以及DPD(二氢嘧啶脱氢酶)mRNA的表达对替吉奥化疗疗效的预测作用。方法应用替吉奥治疗晚期胃癌患者34例,对患者外周血中的TS mRNA以及DPD mRNA的表达情况进行检测,并与化疗效果之间的关系进行评价。结果替吉奥治疗有效患者的TS mRNA值为(1.57±0.31),无效患者的TS mRNA值为(2.83±0.43),差异有统计学意义(P<0.05);替吉奥治疗有效患者的DPD mRNA值为(1.15±0.37),无效患者的DPD mRNA值为(0.98±0.22),差异无统计学意义(P>0.05)。结论外周血中TS mRNA低表达的患者对口服替吉奥化疗的敏感性高,疗效较好,但口服替吉奥化疗的疗效与外周血中DPD mRNA的表达情况无显著相关。
Objective To evaluated the prediction of TS and DPD mRNA in peripheral blood on the effect of S -1 for ad-vanced gastric cancer .Methods Expression of TS and DPD mRNA in peripheral blood of 34 cases of advanced gastric cancer patients treated with S-1 were detected ,and its relationship with effectiveness of chemotherapy were evaluated .Results The val-ue of TS mRNA in patients who were effectively treated with S-1 was (1.57 ±0.31),the value of TS mRNA in patients with inva-lid effect after treated with S-1 was (2.83 ±0.43).The difference had statistical significance (P<0.05).The value of DPD mR-NA in patients with invalid effect after treated with S-1 was(1.15 ±0.37),the value of DPD mRNA in patients with invalid effect after treated with S-1 was(0.98 ±0.22).The difference had no statistical significance (P>0.05).Conclusion Low TS mRNA expression in peripheral blood has high sensitivity after oral S-1 chemotherapy and the curative effect is better .But there is no sig-nificant correlation between oral S-1 chemotherapy and the expression of DPD mRNA in peripheral blood .
出处
《实用癌症杂志》
2014年第7期789-790,793,共3页
The Practical Journal of Cancer
关键词
晚期胃癌
替吉奥
二氢嘧啶脱氢酶
胸腺合成酶
Advanced gastric cancer
S-1
Dihydropyrimidine dehydrogenase(DPD)
Thymidylate synthase(TS)
