摘要
目的研究阴茎癌中胸苷酸合成酶(TS)及二氢嘧啶脱氢酶(DPD)的表达,及其与临床特征的关系。方法纳入我院96例阴茎癌患者的肿瘤组织,采用免疫组化技术,检测TS及DPD表达情况,并分析这些酶表达与患者临床特征之间的关系。结果 TS、DPD在阴茎癌中的表达阳性率分别为41.67%(40/96)和33.33%(32/96),TS与DPD的表达正相关(C=0.362,P<0.01),DPD表达较多见于不吸烟患者(P=0.040)。结论 TS和DPD在阴茎癌组织中一定程度表达,且二者表达正相关。本研究有助于了解阴茎癌的特征,为阴茎癌的氟尿嘧啶类药物化疗提供了有价值的信息。
Objective To investigate the expression of thymidylate synthase(TS)and dihydropyrimidine dehydrogenase(DPD)in penile cancer.Methods A total of 96patients with penile cancer were included,the expression of TS and DPD in tumor tissues were examined by immunohistochemistry method,the relationship of TS and DPD expressions with the clinical characters were also analyzed.Results The expression of TS and DPD in penile cancer tissue were 41.67%(40/96)and 33.33%(32/96)respectively.There was a positive correlation between TS and DPD expression(Pearson C=0.362,P<0.01).DPD was found to be more expressed in nonsmoking patients(P=0.040).Conclusion TS and DPD were moderately expressed in penile cancer and their expressions were positively correlated.This could be helpful for the application of fluorouracil in chemotherapy for the patients with penile cancer.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2013年第5期756-759,共4页
Journal of Sichuan University(Medical Sciences)
关键词
阴茎癌
胸苷酸合成酶
二氢嘧啶脱氢酶
氟尿嘧啶
Penile cancer
Thymidylate synthase
Dihydropyrimidine dehydrogenase
Fluorouracil
