摘要
近100年前,抗菌肽(AMPs)被证实为先天免疫的重要部分。它们独立地存在于体液及体表或通过炎症诱导产生。防卫素具有良好的抗菌活性。BPI(杀菌/通透性增强蛋白)可以减弱局部炎症反应,降低系统性内毒素毒性。在败血症中乳铁蛋白肽HNP1-3、乳铁蛋白、BPI和肝素结合蛋白增加。与抗生素相比,AMPs既可以杀菌,也能中和致病因素如脂多糖。基于此,重点综述在败血症中天然和合成的AMPs作用及未来发展前景。
Nearly 100 years ago, antimicrobial peptides(AMPs) were confirmed as an important part of innate immunity. They can independently exist in the body fluids and body surface or by inflammation induced. Defense has good antibacterial activity. BPI(bactericidal/permeability enhanced protein) can reduce the local inflammation, reduce systemic toxici ty of endotoxin. Lactoferrin peptide HNP1-3 in sepsis, lactoferrin, BPI, and heparin binding protein increased. Compared with antibiotics, AMPs can sterilization, and can neutralize pathogenic factors such as fat polysaccharide. This paper focused on AMPs of natural and synthetic role in sepsis and future development prospect.
出处
《生物化工》
2016年第4期82-83,共2页
Biological Chemical Engineering
关键词
败血症
抗菌肽
治疗
Sepsis
Antibacterial peptide
Treatment
