摘要
目的总结了骨关节炎的发病机制和微球给药系统在骨关节炎治疗领域的研究进展,为临床上骨关节炎的研究和治疗提供理论支持。方法参考近年来国内外关于骨性关节炎的文献,对骨关节炎的发病机制和治疗方法进行综述。结果目前骨性关节炎的治疗,逐渐从缓解症状向发病机制方面深入研究,进一步揭示了骨性关节炎治疗的内在规律性。然而,中西医疗法都有各自的局限性。结论近年来关节腔注射给药治疗骨性关节炎显示出独特的优势,尤其以微球为载体的注射剂,在新剂型领域研究的较多,具有优越的发展前景。
Objective To review the pathogenesis of osteoarthritis ( OA) and microsphere delivery systems advances in the field of osteoarthritis treatment, and provide theoretical support for clinical research and osteoarthritis therapy.Methods The literatures on osteoarthritis have been reviewed in recent years, and pathogenesis and osteoarthritis therapy were summarized.ResuIts At present, the therapy of OA was gradually from symptoms relief to pathogenesis, and further revealed the inner regularity of osteoarthritis treatment.However, a variety of western medicines had its own limitations. ConcIusion In recent years, intra-articular injection therapy because of its unique advantages in clinical treatments,attracts widespread attention, and particularly the microsphere injection with superior prospects is researched more in the field of new formulations.
出处
《中国生化药物杂志》
CAS
2015年第7期185-188,共4页
Chinese Journal of Biochemical Pharmaceutics
