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慢性心力衰竭患者血压变异性、血清超敏肌钙蛋白水平变化及意义 被引量:8

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摘要 目的探讨慢性心力衰竭(CHF)患者血压变异性(BPV)及血清超敏肌钙蛋白(hs-Tn)水平变化的临床意义。方法选择CHF患者140例(CHF组),心功能分级Ⅰ级40例、Ⅱ级40例、Ⅲ级40例、Ⅳ级20例,同期健康体检者40例(对照组)。采用电化学发光免疫法检测两组血清hs-Tn水平;采用Spacelabs90217动态血压监测仪记录BPV相关指标,即白天、夜间和24 h收缩压变异性(d SSD、n SSD、24SSD)及标准差(SBPSD),白天、夜间和24 h舒张压变异性(d DSD、n DSD、24DSD)及标准差(DBPSD),24 h平均收缩压变异系数(SBPCV)及24 h平均舒张压变异系数(DBPCV);分析hs-Tn与BPV相关指标的关系。结果 CHF组SBPSD、DBPSD、SBPCV、DBPCV均较对照组升高(P均<0.05)。CHF组24SSD、24DSD、n SSD、n DSD、d SSD、d DSD均随心功能分级增加而升高(P均<0.01)。CHF组血清hs-Tn水平为(0.90±0.17)pg/m L,对照组为(0.70±0.01)pg/m L;两组比较,P<0.05。CHF组心功能Ⅰ、Ⅱ、Ⅲ、Ⅳ级血清hs-Tn分别为(0.31±0.02)、(0.67±0.03)、(0.72±0.03)、(0.89±0.02)pg/m L,两两比较,P均<0.05。CHF组血清hs-Tn水平与24SSD、24DSD、n SSD、n DSD、d SSD、d DSD、SBPSD均相关(P均<0.05)。结论CHF患者血清hs-Tn及BPV相关指标水平均升高,且其水平随NYHA心功能分级增加而升高;血清hs-Tn水平可间接反映心肌损伤程度。
出处 《山东医药》 CAS 北大核心 2015年第32期50-52,共3页 Shandong Medical Journal
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