摘要
目的探讨新辅助化疗联合保乳手术治疗早期乳腺癌的近期临床疗效及安全性。方法回顾性分析我院治疗的早期乳腺癌患者60例,根据治疗法的不同分为观察组和对照组各30例,观察组采用新辅助化疗后保乳手术,对照组采用改良保乳手术,比较二者临床效果。结果观察组患者手术时间、术中出血量及术后住院时间均优于对照组,差异有统计学意义(P<0.05)。观察组患者术后并发症发生率13.33%,低于对照组的40.00%,差异有统计学意义(P<0.05)。两组患者术后1年治疗效果相似,差异无统计学意义(P>0.05)。治疗前,两组患者QLQ-C30量表各项评分相似,差异无统计学意义(P>0.05);术后1年,观察组QLQ-C30量表各项评分与治疗前相似,差异无统计学意义(P>0.05);对照组QLQ-C30量表各项评分较治疗前降低,差异有统计学意义(P<0.05)。结论早期乳腺癌采用新辅助化疗联合保乳手术治疗,既能达到治疗肿瘤的目的,又能保留乳房形态的美观,值得临床推广应用。
Objective To discuss clinical effects and safety of the combined therapy of neoadjuvant chemotherapy and breast-conserving surgery for treatment of early-stage breast cancer. Method Retrospective analysis 60 cases of early-stage breast cancer who were treated in our hospital,According to the different treatment methods,30 cases were distributed into the observation group,another 30 cases were distributed into the control group,patients in the observation group were treated with the combined therapy of neoadjuvant chemotherapy and breast-conserving surgery,and patients in the control group were treated with improved breast-conserving surgery,clinical effects of the two groups were compared. Results In the observation group,operation time,intr-aoperatve blood soss and postoperative hospitalization duration of the patients were superior to that in the control group,the differ-ences had statistical significance ( P < 0. 05 ) . Occurrence rate of postoperative complications in the observation group was 13. 33%,while occurrence rate of postoperative complications in the control group was 40%,The difference had statistical signifi-cance(P<0. 05). In the two groups,therapeutic effects of the patients within 1 year after operation were similar,the difference had no statistical significance(P>0. 05). Before treatment,all items of QLQ-C30 scores in the two groups were similar,the difference had no statistical significance(P>0. 05). In 1 year after operation,all items of QLQ-C30 scores in the observation group were sim-ilar to the scores before treatment,the difference had no statistical significance(P>0. 05),however,QLQ-C30 scores in the control group reduced,the difference had statistical significance( P<0. 05 ) . Conclusion The combined therapy of neoadjuvant chemo-therapy and breast-conserving surgery can not only be used for treating early-stage breast cancer,also can maintain beautiful form of breasts,the therapy is worthy of clinical popularization and application.
出处
《四川医学》
CAS
2014年第11期1440-1442,共3页
Sichuan Medical Journal
关键词
乳腺癌
早期
新辅助化疗
保乳手术
breast cancer
early stage
neoadjuvant chemotherapy
breast-conserving surgery
