摘要
目的探讨妊娠期妇女骨密度(BMD)变化趋势及骨代谢特征。方法选取2016年1月至2018年1月在宁波市北仑区人民医院分娩的妊娠妇女200例作为妊娠组,同时选取健康妇女150例作为对照组,分别检测对照组和妊娠组早孕期、中孕期和晚孕期BMD、血清钙、碱性磷酸酶(ALP)、骨钙素(BGP)、尿钙/尿肌酐(Cr)、尿脱氧吡啶啉(DPD)/Cr水平。结果妊娠组晚孕期BMD为(0.45±0.07)g/cm^2,低于中孕期、早孕期水平及对照组(t值分别为11.16、12.40、11.69,均P<0.05);对照组和妊娠组各孕期血清钙水平比较差异无统计学意义(均P>0.05);妊娠组晚孕期血清ALP、尿钙/Cr及尿DPD/Cr明显高于中孕期、早孕期水平及对照组(ALP:t值分别为16.12、24.15、25.12;尿钙/Cr:t值分别为9.20、28.04、33.71;尿DPD/Cr:t值分别为19.26、27.64、34.32,均P<0.05),而血清BGP明显低于中孕期、早孕期水平及对照组(t值分别为9.03、15.86、17.19,均P<0.05)。孕妇晚孕期BMD与血清ALP、尿钙/Cr及尿DPD/Cr呈负相关(r分别为-0.46、-0.42、-0.43,均P<0.05),与BGP呈正相关(r=0.38,P<0.05)。结论妊娠期妇女BMD有所降低,尤其晚孕期下降明显,与骨代谢指标有一定相关性。
Objective To investigate the change trend of bone mineral density(BMD) and bone metabolism in pregnant women. Methods Two hundred pregnant women(pregnancy group) who delivered in Beilun District People’s Hospital of Ningbo City from January 2016 to January 2018 were selected, and 150 healthy women were selected as control group. The levels of BMD, serum calcium, alkaline phosphatase(ALP), bone gla protein(BGP), urinary calcium/urinary creatinine(Cr) and urine deoxypyridine(DPD)/Cr were detected in the control group and the pregnancy group during early pregnancy, middle pregnancy and late pregnancy. Results In late pregnancy, BMD was 0.45±0.07 g/cm^2 in pregnancy group, which was lower than the level in middle pregnancy and early pregnancy and that in the control group(t value was 11.16, 12.40 and 11.69, respectively, all P<0.05). There was no significant difference in serum calcium levels between the control group and pregnancy group(all P>0.05). The serum ALP, urinary calcium/Cr and urine DPD/Cr in late pregnancy in pregnancy group were significantly higher than those in middle pregnancy and early pregnancy and those in the control group(ALP:t value was 16.12, 24.15 and 25.12;urinary calcium/Cr :t value was 9.20, 28.04 and 33.71;urine DPD/Cr:t value was 19.26, 27.64 and 34.32, respectively, all P<0.05), but the serum BGP was obviously lower than in middle pregnancy and early pregnancy and that in the control group(t value was 9.03, 15.86 and 17.19, respectively, all P<0.05). BMD in late pregnancy was negatively correlated with serum ALP, urinary calcium/Cr and urine DPD/Cr(r value was-0.462,-0.419 and-0.43, respectively, all P<0.05), but was positively correlated with BGP(r=0.38,P<0.05). Conclusion BMD in pregnant women is decreased, especially in late pregnancy, which is correlated with bone metabolism index.
作者
丁莉
顾海燕
陈玲英
DING Li;GU Haiyan;CHEN Lingying(Department of Gynecology,Beilun District People’s Hospital of Ningbo City,Zhejiang Ningbo 315800,China)
出处
《中国妇幼健康研究》
2019年第2期236-239,共4页
Chinese Journal of Woman and Child Health Research
关键词
妊娠期
骨密度
骨代谢
早孕期
中孕期
晚孕期
pregnancy
bone mineral density(BMD)
bone metabolism
early pregnancy
middle pregnancy
late pregnancy
