摘要
目的 观察基因重组人生长激素(rhGH)对生长激素缺乏症(GHD)患儿的疗效。方法 对15例GHD患儿应用rhGH治疗,每晚睡前皮下注射0.1 IU/kg,疗程6个月。结果 患儿身高由治疗前109.3±9.9cm增加到115.5±11.3 cm;年身高生长速度由治疗前2.8±0.6cm/年增加到11.6±3.5cm/年。治疗期间除少数患儿出现亚临床甲状腺功能低下,注射部位有轻度反应外,未发现明显副作用。结论 皮下注射rhGH是治疗儿童GHD的一种安全有效的方法。
Objective To investigate the therapeutic effect of recombinant growth hormone(rhGH) in growth hormone deficient (GHD)children before adolescence. Methods This study included 15 children( 13 boys and 2 girls) with GHD, who were treated with subcutaneous injections of rhGH 0.1 IU/(kg'd) before sleep for 6 months. Results The mean height and mean growth velocity increased from 109.3 + 9.9cm to115.5+11.3 cm, from 2.8 + 0.6 cm per, to 11.6+3.5 cm per respectively. During the course of rhGH therapy, no remarkable adverse effect was found,except that fewer patients suffered from subclinical hypothyroidiam and local reactions in injection sites. Conclusion Recombinant growth hormone is an effective and safe drug for promoting height growth in GHD children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2003年第8期598-600,共3页
Journal of Applied Clinical Pediatrics
关键词
生长激素缺乏症
重组人生长激素
儿童
growth hormone deficiency
recombinant human growth hormone
children
