摘要
血友病A是由于FⅧ基因缺陷、X连锁的遗传性疾病。我们应用与Ⅷ紧密连锁的DNA片段作为探针,用TaqI限制性片段长度多态性对一血友病A家系进行了基因诊断。
Hemophilia A is a commoaly inherited disease of blood coagulation. The disorder is caused by deficiency in gene for factor Ⅷ and inherited as an X-linked trait. By use of cloned factor Ⅷ DNA fragment as a probe, Taq I Restriction Fragment Length Polymorphisms (RFLPs) located within the factor Ⅷ gere was studied. By use of the RFLPs, A family with hemophilia A was analysed.
关键词
血友病A
RFLP_s
基因诊断
hemophilia A
Restriction Fragment Polymorphisms
DNA diagnosis
