摘要
目的 探讨应用血清α- GST监测肝移植术后移植肝缺血再灌注损伤的临床价值。方法 采用酶联免疫测定法(EIA)对 30例原位肝移植受体移植肝恢复再灌注 72 h内血清α- GST水平的动态变化进行监测 ,并与常规肝功能指标 (AST、AL T、L DH)比较。结果 移植肝恢复再灌注后血清α- GST水平迅速上升、迅速下降 ,达到高峰及降至正常的时间明显早于肝功能指标 ,平均每小时变化率及平均峰值幅度也明显大于同期肝功能指标。结论 血清α- GST监测肝移植术后移植肝缺血再灌注损伤较常规肝功能指标更具敏感性 。
Objective This study was undertaken to determine the value of serum α GST monitorting the hepatic funetion when the liver graft enduring reperfusion injury.Methods Serum α GST levels and conventional liver function paremeters(AST?ALT?LDH)were determined in 30 consecutive liver transplant recipients.All experimental paramentas were determined at predefined time points before reperfusion and after reperfusion:15 min and 1,2,4,8,12,18,24,48 and 72 hr.Results Serum α GST,AST,ALT and LDH levels all showed rapid increase tendencies and then reached their peaks,followed by progressive decrease tendencies.Serum α GST level reached its peak on the first hour after reperfusion,and returned to normal by the 18th hour after reperfusion.There were significant differences between α GST andAST,ALT and LDH in the time to reach the peaks and in the time to reach the normal.There was sigmificant greater maximal level and greater rate of median change per hour in α GST after reperfusion when compared with that in ALT,AST and LDH,respectively.Conclusion α GST seems to be a more sensitive indicator over conventional liver function tests when monitoring liver reperfusion injury following transplantation.
出处
《肝胆外科杂志》
2003年第4期271-273,共3页
Journal of Hepatobiliary Surgery
关键词
谷胱甘肽-S-转移酶
缺血再灌注损伤
肝功能
肝移植
glutathione s transferase,Ischemia reperfusion injury,liver function,Liver transplantation.
