摘要
目的观察手术前、手术后第１ｄ、手术后第６ｄ血浆纤维蛋白原（ＦＢＧ）、白细胞介素６（ＩＬ－６）的水平变化及探讨其临床意义。方法分别用比浊法、酶联免疫法（ＥＩＡ）对２５例胸外科、普通外科大中手术患者的血浆ＦＢＧ及ＩＬ－６水平进行了检测。结果血浆ＦＢＧ在术后第１ｄ显著高于术前（Ｐ＜０．０１），且逐渐增高，至术后第６ｄ仍显著高于术前（Ｐ＜０．０１）；血浆ＩＬ－６水平术后第１ｄ显著高于术前（Ｐ＜０．０１），此后逐渐下降，但术后第６ｄ仍未下降至术前水平（Ｐ＜０．０５）；术后第１ｄ血浆ＦＢＧ与ＩＬ－６呈明显正相关（ｒ＝０．４５５６，Ｐ＜０．０５）。
Objective To evaluate the clinical implication of changes of plasma fibrinogen and interleukin 6(IL 6)in patients undergoing surgery.Methods\ Turbidimetric method for the levels of plasma FBG and EIA analysis for the levels of plasma IL 6 were performed in 25 patients preoperatively and on lst and 6th day postoperatively.Results\ The average plasma FBG and IL 6 levels were increased significantly on the 1st day portoperatinly compared with preoperatively(P<0 01).There was a significant correlation between the average plasma FBG levels and IL 6 levels on the 1st day after operations (P<0 05,r=0 46).The average plasma IL 6 levels reduced quickly on 1st day after the operation However,the plasma FBG maintained higher levels and still did not drop by the 6th day after operation.Conclusion Our data demonstrate that there is positive correlation between plasma FBG and IL 6.However,it is only maintained for a short time after operation.This shows that the elevation of plasma levels of FBG may be a respones partially by IL 6.
出处
《中国实验诊断学》
1998年第6期307-308,共2页
Chinese Journal of Laboratory Diagnosis
