摘要
目的探讨老年患者纤维蛋白原(fibrinogen,Fib)增高的病因、伴发因素和临床特点。方法对50例纤维蛋白原测定值增高的老年患者(Fib增高组)和45例纤维蛋白原测定值正常老年患者(对照组)的检验项目结果和临床诊断进行比较分析。结果老年Fib增高组患者较对照组患者的活化部分凝血活酶(activated partial thromboplastin time,APTT)、红细胞沉降率(erythrocyte sedimentation rate,ESR)、血小板(blood platelet,PLT)测定值增高,血清总胆固醇(total cholesterol,TC)降低,差异均具有统计学意义。临床诊断分析显示Fib增高组老年患者的急重症和血栓性疾病的发病率明显高于对照组。结论老年患者纤维蛋白原增高提示其急重症和血栓性疾病的发生危险性增大。
Objective To explore the causes of elevated fibrinogen（Fib） and factors associated with clinical features in elderly patients. Methods The clinical and laboratory data of 50 elderly patients with high Fib（high Fib group） and 45 elderly patients with normal Fib（control group） were analyzed and compared. Results As compared with the control group, the patients in the high Fib group had significantly higher activated partial thromboplastin（APTT）, erythrocyte sedimentation rate（ESR）, and blood platelet（PLT） while their total cholesterol（TC ） was significantly reduced. Analysis of clinical diagnosis indicated that high Fib group of elderly patients had significantly more acute severe disease and higher incidence of thrombosis than those in the control group of elderly patients. Conclusion Increased fibrinogen in elderly patients may suggest higher risks for severe acute disease and the occurrence of thrombotic disorders.
出处
《首都医科大学学报》
CAS
北大核心
2010年第1期72-74,共3页
Journal of Capital Medical University
基金
国家自然科学基金(30672469)
北京市自然科学基金(7062030)资助项目~~
