摘要
目的:探讨补肾养膜汤配合氯米芬对肾虚血瘀型多囊卵巢综合征患者生殖功能的影响。方法:将收治的多囊卵巢综合征患者120例,按随机抽签法分为观察组和对照组各60例,对照组采用氯米芬治疗,观察组在对照组基础上加用补肾养膜汤治疗,3个月经周期后比较2组临床疗效和治疗前后中医证候积分、血清性激素水平改善情况,以及周期排卵率、优势卵泡直径、排卵日子宫内膜厚度、临床妊娠率及不良反应。结果:观察组治疗总有效率为90.00%,高于对照组75.00%(P <0.05)。治疗前,2组患者主证及次证积分比较,差异无统计学意义(P> 0.05)。治疗后,2组主证及次证积分均较治疗前降低,且观察组低于对照组(P <0.05)。治疗前,2组睾酮(T)、黄体生成素(LH)、促卵泡刺激素(FSH)、LH/FSH水平比较,差异无统计学意义(P>0.05)。治疗后,2组T、LH及LH/FSH水平均较治疗前降低,FSH水平较治疗前升高。治疗后,观察组T、LH及LH/FSH水平低于对照组,FSH水平显著高于对照组(P <0.05)。观察组周期排卵率及周期妊娠率均高于对照组,优势卵泡直径大于对照组(P <0.05),排卵日子宫内膜厚度大于对照组(P <0.001)。观察组不良反应发生率低于对照组(χ~2=4.227,P <0.05)。结论:补肾养膜汤配合氯米芬治疗肾虚血瘀型多囊卵巢综合征患者可显著提高临床疗效,改善患者的生殖功能,提高临床妊娠率。
Objective:To discuss the effect of Bushen Yangmo tang combined with clomiphene on reproductive function of patients with polycystic ovary syndrome of kidney deficiency and blood stasis type.Methods:120 cases of patients with polycystic ovary syndrome hospitalized and treated in our hospital were divided into the observation group and the control group randomly,60 cases in each group.The control group received clomiphene,while the observation group additionally received Bushen Yangmo tang.After 3 menstrual cycles,compared the clinical effect,Chinese medicine syndrome scores,improvements in levels of serum sex hormones,the ovulation rate per cycle,diameter of the dominant follicle,endometrial thickness on the day of ovulation,clinical pregnancy rate and adverse reactions before and after treatment in both groups.Results:The total effective rate was 90.00%in the observation group,being higher than 75.00%in the control group(P<0.05).Before treatment,comparing the scores of major symptoms and minor symptoms in both groups,there was no significant difference being found(P>0.05).After treatment,the scores of major symptoms and minor symptoms in both groups were lower than those before treatment,and each score in the observation group was lower than that in the control group(P<0.05).Before treatment,comparing the levels of testosterone(T),luteinizing hormone(LH),follicle-stimulating hormone(FSH)and LH/FSH in both groups,there was no significant difference being found(P>0.05).After treatment,the levels of T,LH and LH/FSH in both groups were lower than those before treatment,and the level of FSH was higher than that before treatment;the levels of T,LH and LH/FSH in the observation group were lower than those in the control group,and the level of FSH was higher than that in the control group(P<0.05).The ovulation rate per cycle and the pregnancy rate per cycle in the observation group was both higher than those in the control group,the diameter of the dominant follicle was larger than that in the control group(P<0.05),and t
作者
黄亚哲
陈建玲
吴佩蔚
李莹
HUANG Yazhe;CHEN Jianling;WU Peiwei;LI Ying
出处
《新中医》
CAS
2019年第6期210-213,共4页
New Chinese Medicine
关键词
多囊卵巢综合征
肾虚血瘀型
补肾养膜汤
氯米芬
中西医结合疗法
Polycystic ovary syndrome
Kidney deficiency and blood stasis type
Bushen Yangmo tang
Clomiphene
Integrated Chinese and western medicine therapy
