摘要
目的观察补肾活血促卵方对血瘀型多囊卵巢综合征所致不孕症的临床疗效。方法随机选取肾虚血瘀型多囊卵巢综合征所致不孕症患者,其中40例作为试验组,40例作为对照组。从月经第5天,试验组患者开始服用补肾活血促卵方,每次服用200 m L,每日1剂,早晚2次服用,连服14 d;对照组患者开始服用克罗米芬,每次50~100 mg,每日1次,连服5 d,治疗3~6个月。用彩色多普勒超声诊断仪检测患者子宫内膜、卵泡的发育情况;用化学发光免疫法检测患者的胰岛素(INS)、促黄体激素(LH)、促卵泡激素(FSH)、垂体泌乳素(PRL)、睾酮(T)、雌二醇(E2)水平;用自拟定的疗效诊断标准计算患者的排卵率、妊娠率。比较2组治疗前后患者的排卵率、妊娠率、卵泡数量、血清性激素、子宫内膜厚度及卵巢体积变化等变化。结果对照组与试验组的妊娠率分别为30%,55%,组间比较差异均有统计学意义(P<0.05);对照组与试验组的排卵率分别为73%,59.4%,组间比较差异均有统计学意义(P<0.05)。与治疗前比较,对照组的FSH、E2差异有统计学意义(均P<0.05);试验组的FSH、T、PRL、LH、INS及E2差异均有统计学意义(均P<0.05)。治疗前,对照组与试验组患者的双侧卵巢直径2~9 mm的卵泡数量分别为(15.8±1.9),(16.6±2.1)个;2组的子宫内膜厚度分别为(6.9±1.48),(6.35±1.52)mm;2组的卵巢体积分别为(11.23±4.12),(10.51±4.51)m L。治疗后,对照组与试验组患者的卵泡数量分别为(12.9±2.2),(9.8±1.0)个;2组的子宫内膜厚度分别为(7.96±2.1),(9.82±1.02)mm;2组的卵巢体积分别为(9.75±3.8),(8.15±2.35)m L。与治疗前比较,试验组患者的卵泡数量、子宫内膜厚度、卵巢的体积,差异均有统计学意义(P<0.05);而对照组患者的卵泡数量、子宫内膜厚度及卵巢的体积差异均无统计学意义(P>0.05)。说明补肾活血促卵方对肾虚血瘀型多囊卵巢综合征有明显的改善作用。结论补肾活血�
Objective To investigate the clinical efficacy of Bushen Huoxue Culuan Prescriptionin in the treatment of regional kidney and blood stasis due to polycystic ovary syndrome （POS）. Methods Forty patients with infertility due to POS with regional kidney deficiency and blood stasis syndrome were randomly selected 40 cases as the treatment group and 40 as the control group. From the fifth day of menstruation, patients in the treatment group began taking Bushen Huoxue and promoting the ovulation, each taking 200 mL, daily one, sooner or later twice, even for 14 days; the control group began days. Treatment of 3 to 6 months. In the course of taking clomiphene once daily, times 50 - 100 mg, even for 5 treatment, color Doppler ultrasonography was used to detect the development of endometrium and follicles. The levels of serum sex hormones, such as insulin （ INS）, luteinizing hormone （ LH）, follicle stimulating hormone （ FSH）, pituitary prolactin （ PRL）, testosterone （T）, estradiol （E2） were measured by chemiluminescence immunoassay. The ovulation rate and pregnancy rate of the patients were calculated by using self- defined diagnostic criteria. The ovulation rate, pregnancy rate, follicle number, serum sex hormone, endometrial thickness and ovarian volume change were compared between the two groups. Results The pregnancy rate were 30% ,55% in control and treatment groups, the difference between the two groups was significant （P 〈 0. 05 ）. The ovulation rate were 73% ,59.4% in control and treatment groups, the difference between the two groups was significant（P 〈 0. 05）. Compared with before treatment, the FSH, E2 in control group were statistically significant （P 〈 0. 05 ） ; the FSH, T, PRL, LH, INS and E2 in treatment group were statistically significant （ P 〈 0. 05 ）. Before treatment, the number of follicles with bilateral ovary diameters of 2 - 9 mm in control and treatment groups were 15.8 ± 1.9, 16. 6±2. 1 ; the thickness of endometrium were （6. 9 ± 1.48）, �
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2017年第9期786-789,共4页
The Chinese Journal of Clinical Pharmacology
基金
海南省卫生厅科研立项基金资助项目(琼卫2011-53)
关键词
补肾活血促卵方
多囊卵巢
不孕症
Bushen Huoxue Culuan Prescription
polycystic ovary
infertility
