摘要
目的:探讨保胎灵辅助治疗肾虚证先兆流产的临床疗效及对肿瘤坏死因子-α(TNF-α)、孕激素诱导阻滞因子(PIBF)水平的影响。方法:将先兆流产患者68例随机分为对照组34例和治疗组34例;对照组给予地屈孕酮片治疗,治疗组在对照组的基础上口服保胎灵片;2组疗程均为2周,观察比较2组血止和腰酸、腹痛缓解时间、妊娠结局及临床疗效,并检测2组患者血清TNF-α、PIBF水平。结果:临床疗效总有效率治疗组为94.12%,对照组为73.53%,2组比较,差异有统计学意义(P<0.05)。正常妊娠率治疗组为91.18%,对照组为67.65%,2组比较,差异有统计学意义(P <0.05)。治疗后,治疗组患者血止和腰酸、腹痛缓解时间均明显短于对照组(P <0.05)。治疗后,2组血清TNF-α水平较治疗前降低(P <0.05),PIBF水平明较治疗前升高(P <0.05);且治疗组上述两项指标改善较对照组更显著(P <0.05)。结论:在地屈孕酮片治疗的基础上,保胎灵辅助治疗肾虚证先兆流产能提高临床疗效及正常妊娠率,迅速改善患者临床症状,其机制可能与调节体内TNF-α、PIBF水平有关。
Objective:To explore the clinical effect of Baotailing in adjuvant treatment of threatened abortion with kidney deficiency syndrome and its effect on the levels of serum tumor necrosis factor-α(TNF-α)and progesterone-induced blocking factor(PIBF).Methods:Divided 68 cases of patients with threatened abortion into the control group and the treatment group randomly,34 cases in each group.The control group received dydrogesterone tablets,while the treatment group additionally received the oral administration of Baotailing tablets.The treatment for both groups lasted for two weeks.Observed and compared the time of hemostasis and relief in waist soreness and abdominal pain,pregnancy outcome and clinical effect in both groups,and detected the levels of serum TNF-αand PIBF of patients in both groups.Results:The total effective rate was 94.12%in the treatment group and 73.53%in the control group,difference being significant(P<0.05).The rate of normal pregnancy was 91.18%in the treatment group and 67.65%in the control group,difference being significant(P<0.05).After treatment,the time of hemostasis and relief in waist soreness and abdominal pain in the treatment group was significantly shorter than that in the control group respectively(P<0.05).After treatment,the level of serum TNF-αin both groups was lower than that before treatment(P<0.05),and the level of PIBF was higher than that before treatment(P<0.05);the two indexes above in the treatment group were improved more significantly than those in the control group(P<0.05).Conclusion:Based on dydrogesterone tablets,Baotailing in adjuvant treatment of threatened abortion with kidney deficiency syndrome can promote the clinical effect and the rate of normal pregnancy and quickly improve the clinical symptoms of patients.Its functional mechanism may be related to adjusting the levels of serum TNF-αand PIBF.
作者
吕小慧
许张晔
LYU Xiaohui;XU Zhangye
出处
《新中医》
CAS
2019年第5期193-195,共3页
New Chinese Medicine
关键词
先兆流产
保胎灵
肾虚证
妊娠结局
TNF-Α
PIBF
Threatened abortion
Baotailing
Kidney deficiency syndrome
Pregnancy outcome
TNF-α
PIBF
