摘要
目的:观察葛根芩连汤对溃疡性直肠炎患者外周血中C-反应蛋白(CRP)、白细胞介素-8 (IL-8)的影响。方法:纳入溃疡性直肠炎患者60例,按照随机数字表法将其分为2组各30例。观察组采用葛根芩连汤基础方灌肠,对照组采用复方黄柏液灌肠。治疗半个月,观察并记录2组用药前后的症状(腹痛、肛门灼热或坠胀、里急后重感等)、体征,用以评价临床疗效,采用酶联免疫吸附法(ELISA)检测2组血清中的CRP、IL-8的水平变化并使用电子结肠镜检测2组治疗前后肠黏膜变化情况。结果:总有效率观察组为93.3%,对照组为73.3%,2组比较,差异有统计学意义(P <0.05)。治疗前,2组CRP、IL-8比较,差异无统计学意义(P> 0.05)。治疗后,2组CRP、IL-8均较前改善(P <0.05),观察组改善优于对照组(P <0.05)。治疗前,2组肠黏膜病变记分比较,差异无统计学意义(P> 0.05)。2组治疗后肠黏膜病变记分下降(P <0.05),观察组治疗后记分低于对照组(P <0.05)。结论:葛根芩连汤保留灌肠治疗湿热下注型溃疡性直肠炎患者,能改善患者的症状、体征,明显改善炎症。
Objective:To observe the effect of Gegen Qinlian tang on C-reactive protein(CRP)and interleukin-8(IL-8)in peripheral blood in the patients with ulcerative proctitis.Methods:A total of 60 cases of patients with ulcerative proctitis were included and divided into two groups according to random number table method,30 cases in each group.The observation group was performed enema with Gegen Qinlian tang,while the control group was performed enema with compound Huangbai liquid.The course of treatment lasted for half a month.The symptoms including abdominal pain,burning sensation or bulge in anus and abdominal urgency with rectal heaviness,and body signs in the two groups were observed and recorded before and after treatment to evaluate the clinical effect.The changes in the levels of CRP and IL-8 in serum in the two groups were detected by enzyme-linked immunosorbent assay(ELISA),and the changes of intestinal mucosa in the two groups were detected by electronic colonoscopy before and after treatment.Results:The total effective rate was 93.3%in the observation group and 73.3%in the control group,the difference being significant(P<0.05).There was no significant difference being found in the comparisons of the levels of CRP and IL-8 before treatment(P>0.05).After treatment,the levels of CRP and IL-8 in the two groups were improved when compared with those before treatment(P<0.05),and the improvement in the observation group was better than that in the control group(P<0.05).Compared the scores of lesions of intestinal mucosa in the two groups before treatment,there was no significance in the difference(P>0.05).The scores of lesions of intestinal mucosa were decreased in the two groups after treatment(P<0.05),and the score of lesions of intestinal mucosa in the observation group was lower than that in the control group after treatment(P<0.05).Conclusion:Retention enema with Gegen Qinlian tang can improve the symptoms and body signs of patients with ulcerative proctitis of damp-heat pouring downward type,and significantly im
作者
魏琳玲
王微
陈红
郁一波
WEI Linling;WANG Wei;CHEN Hong;YU Yibo
出处
《新中医》
CAS
2019年第4期65-68,共4页
New Chinese Medicine
