摘要
目的探讨血清中维生素D(25-羟基维生素D)和维生素D结合蛋白与肺癌的相关性及在肺癌诊疗中的意义。方法随机抽取广州医科大学附属第一医院197名肺癌患者及29名健康体检者作为样本,分别作为观察组和对照组,采用电化学发光技术检测两组样本中维生素D(25(OH)D)的浓度,采用ELISA法检测样本中维生素D结合蛋白浓度,通过对比两组样本中维生素D结合蛋白含量的差异阐明二者与肺癌之间关系,并分析其与患者临床病理特征之间的关系。结果观察组患者的血清维生素D水平为(19.72±7.92)ng/mL,对照组为(19.81±6.76)ng/mL,组间差异无统计学意义(P>0.05);观察组腺癌患者的血清维生素D水平(18.60±7.91)ng/mL,鳞状细胞癌患者(23.27±7.49)ng/mL,小细胞癌患者(21.50±7.57)ng/mL,其中鳞状细胞癌与腺癌患者比较差异有统计学意义(P<0.05),其余组间比较差异无统计学意义(P>0.05)。观察组患者的血清维生素D结合蛋白水平是35.80(91.31)μg/mL,对照组是115.82(49.05)μg/mL,组间比较差异有统计学意义(P<0.05)。观察组中腺癌患者的血清维生素D结合蛋白水平39.90(113.93)μg/mL,鳞癌患者42.15(65.69)μg/mL,小细胞癌患者30.81(110.20)μg/mL,各组间比较差异均无统计学意义(P>0.05)。结论血清维生素D水平与肺癌的相关性仍需进一步深入及大样本研究;血清维生素D结合蛋白水平与肺癌具备相关性,监测患者维生素D结合蛋白水平有利于及时发现异常情况。
Objective To explore the correlation between serum vitamin D(25-hydroxyl vitamin D)and vitamin D binding protein(VDBP)and lung cancer,and their significance in the diagnosis and treatment of lung cancer.Methods 197 lung cancer patients and 29 healthy subjects in the First Affiliated Hospital of Guangzhou Medical University were randomly selected as the observation group and the control group,respectively.The concentration of vitamin D in the serum was detected by electrochemical luminescence technique,and the concentration of VDBP in the serum was detected by ELISA.The relationship between vitamin D-binding protein and lung cancer was elucidated by comparing the difference in vitamin Dbinding protein content between the two groups,and the relation of the clinical pathological features between patients was analyzed.Results There was no significant difference between concentration of vitamin D level in the observation group[(19.72±7.92)ng/mL]and the control group[(19.81±6.76)ng/mL](P>0.05).For vitamin D,there was significant difference between the squamous cell carcinoma[(23.27±7.49)ng/mL]and the adenocarcinoma[(18.60±7.91)ng/mL]in the observation group,except the small cell cancer((21.50±7.57)ng/mL)There was significant difference between vitamin D binding protein level in the observation group[35.80(91.31)μg/mL]and the control group[115.82(49.05)μg/mL](P<0.05),indicating that vitamin D binding protein level was associated with lung cancer.For vitamin D binding protein,there was no significant difference among the squamous cell carcinoma[42.15(65.69)μg/mL],the adenocarcinoma[39.90(113.93)μg/mL]and the small cell cancer[30.81(110.20)μg/mL]in the observation group(P>0.05).Conclusion The correlation of serum vitamin D level and lung cancer still needed further investigation and large sample studies to confirm.The serum vitamin D binding protein levels and lung cancer showed a positive correlation.Monitoring patients vitamin D binding protein level might be conducive to the timely detection of abnormal condi
作者
陈敏琦
吴颖琳
张依
茅立鹏
徐霞
CHEN Min-qi;WU Ying-lin;ZHANG Yi;MAO Li-peng;XU Xia(Guangzhou Medical University,Guangzhou,Guangdong 510030,China)
出处
《热带医学杂志》
CAS
2019年第5期633-636,共4页
Journal of Tropical Medicine
基金
广东省本科高校教学质量与教学改革工程项目(粤教高函[2016]233号)
